silibinin


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silibinin

One of two major constituents of silymarin (silibinins A and B), the main extract of milk thistle (Silybum marianum seeds), which have hepatoprotective effects (e.g., against Amanita phalloides (deathcap mushroom) poisoning) and anti-cancer activity (in animal models) against prostate adenocarcinoma, breast carcinoma cells, cervical carcinoma cells, colon cancer and both small and non-small lung carcinomas. It may also be useful for cirrhosis and type-2 diabetes.
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125) It is important to note that some preparations sold as milk thistle extract, silymarin, or silibinin may contain little, or even no, isosilybin B.
A study published in 2009, conducted by three of the Korean coauthors of the report on the positive effects of mulberry extracts in human glioblastoma discussed above, found that silibinin inhibited human glioblastoma cell proliferation in the lab.
Andy adjusted his supplements in response to the findings in Table 3 by adding EGCG at 472 mg/day, silibinin at 85 mg/day, ginger at 10 mg/day, rosemary extract at 800 mcg/day and also increased his total EPA + DHA dose to 3,600 mg/day.
Conclusions: Our work demonstrated that silibinin is a novel CXCR4 antagonist that may have potential therapeutic use for prevention of tumor metastasis.
Silibinin inhibits translation initiation: implications for anticancer therapy.
Impressive human data for the impact of silibinin on iron-overloaded patients is now available.
Silibinin attenuates adipogenesis in 3T3-L1 preadipocytes through a potential upregulation of the insig pathway.
Recently it was demonstrated that high-dosage silibinin infusion treatment could significantly decrease the number of hepatitis C viruses after four-week application.
Silibinin inhibits ultraviolet B radiation-induced mitogenic and survival signaling, and associated biological responses in SKH-1 mouse skin.
Silymarin, silibinin, and other milk thistle components protect against these and other chemical insults.
Silibinin, the major flavonol ignan of silymarin, has demonstrated interesting preventive and anticancer properties in prostate cancer animal models (Klempner and Bubley, 2012).