signal transduction

(redirected from Signal transduction pathways)
Also found in: Dictionary, Encyclopedia.

signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
Instead, they rely on Janus kinases (JAK) to phosphorylate and activate the downstream proteins in their signal transduction pathways.
The data suggest that reduced utero-placental perfusion induces alterations in leptin levels and signal transduction pathways, contributing to a hyper-responsive uterine vasculature and the development of fetal growth restriction.
University of Nebraska (Lincoln, NE) has patented methods for determining nucleic acid sequences that encode components of signal transduction pathways in higher plants.
The translocation of these proteins is essential for activating a number of signal transduction pathways (7), although their precise role in pathogenesis is not well defined.
The presentation entitled "Snapshot of MAP kinase and related signal transduction pathways from biopsied cells using a novel non-optical assay technology - a proof of concept study" was presented by W.
I propose to use FA cellular models to examine the molecular events leading to CFS instability, and FA mouse models to investigate the consequences of deletions, amplifications or rearrangements involving CFSs on the expression of genes regulating critical signal transduction pathways involved in cell survival, proliferation, and differentiation.
The TheraLink HER Family Assay for primary, recurrent and metastatic breast cancers gives a molecular analysis of each patient's unique cancer, based upon the functional activity of signal transduction pathways known to modulate cancerous growth.
We review recent advances in the understanding of the signal transduction pathways involved in the activation of endothelial NO production and Nrf2-Keap1-mediated antioxidant gene expression by dietary isoflavones.
Phospholipase C[gamma]1 (PLC[gamma]1) is at the point of convergence of signal transduction pathways and plays an important role in regulating cancer progression.
The methods include experimental procedures for visualizing and measuring migration behaviors of different kinds of organisms; methods for studying signal transduction pathways involved in chemotaxis in D.
An emphasis on the genetic pathways in the context of toxic exposure is critical to developing a sense of where toxic exposure may make contact with critical signal transduction pathways that regulate pattern formation.
Assigning proteins to metabolic and signal transduction pathways is a major goal during the process of target identification and validation.

Full browser ?