signal transduction

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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
As a member of the signal transducer and activator of transcription (STAT) family, STAT3 has received much attention during the past decade [8] It is involved in many processes such as immune responses, inflammation, and tumorigenesis.
Primers for real time-PCR analysis Gene category Gene name GenBank ID Primer Growth hormone Growth hormone receptor NM_176608 Forward signaling (GHR) Reverse Signal transducer and NM_174617 Forward activator of Reverse transcription 5B (STAT5B) Insulin-like growth NM_001077828 Forward factor (IGF-1) Reverse Androgen receptor NM_001244127 Forward Reverse Myostatin NM_001001525 Forward Reverse Lipogenesis Fatty acid synthase NM_001012669 Forward (FASN) Reverse Fatty acid binding BT10868 Forward protein 4 (FABP4) Reverse Lipid Adipose triglyceride NM_001046005 Forward metabolism lipase (ATGL) Reverse Acyl-CoA synthetase NM_001076085.
The mechanism by which berberine modulates -germline transcript expression might be through regulating the phosphorylated IkBa level and the expressions of signal transducer and activator of transcription-3 and T-box transcription factor TBX21.
The aim of this proposal, which combines structural biology and live cell imaging, is to understand the function and signalling consequences of the multivalent interactions between Hh signal transducer proteins as well as their spatial and temporal regulation in the primary cilium.
Editor's note: FLLL32 reduced activation of the protein known as signal transducer and activator of transcription 3 (STAT3), which is elevated in approximately 82% of head and neck cancers and has been associated with cisplatin resistance.
We assessed maximal leptin-mediated binding of the transcription factor signal transducer and activator of transcription 3 (STAT3), and the response to high-fat feeding in lean leptin-resistant rats.
The oncology test panels will feature GLG's patented inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3), which are in preclinical development for a new generation of targeted therapies.
Concentrating on cell membrane receptors themselves, together with their immediate signal transducers, this introductory text on receptor pharmacology combines four major approaches in the study of receptors: molecular investigation of receptor structure; quantitative functional studies of agonists and antagonists; ligand binding; and signal transduction at the cell membrane.
Specific topics include a survey of immunology, superantigens, antigen presenting cells, cell mediated immune defense, cytokines as molecular mediators, interleukens, interferons as viral inhibitors and immune response mediators, interferon signaling through Janus kinases and signal transducers and activators of transcription, flow cytometry, immunoassays, genetic engineering of antibody molecules, autoantibodies and autoimmunity, synovial mast cells in inflammatory arthritis and the molecular and cell biology of HIV/AIDS.

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