signal transduction

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signal transduction

n.
The process by which a signal, such as a hormone or a change in the concentration of an ion, is converted into a biochemical response by means of the activation of a receptor on the surface or interior of a cell.

signal transduction

Biochemical conversion that is part of a process, such as the docking of hormone to receptor, stimulating cellular production of specific enzymes or other proteins.
See also: transduction

signal transduction

The common process by which the binding of a molecule to a receptor on a cell plasma membrane results in the transmission of a signal within the cell (second messenger) to trigger off a biochemical pathway in the cell.

signal transduction

control of cellular activity by way of an extracellular signal being transduced into an intracellular response. This involves a cell surface receptor that responds to an external signalling compound by carrying the signal across the cell membrane to influence intracellular activities, such as expression of the genome. For example, the compound may bind to the receptor, altering its conformation, and result in the activation of an intracellular protein by phosphorylation. This, in turn, can initiate the transduction pathway in the cell. Some signals to which cells respond are ANTIGENS, HORMONES, GROWTH FACTORS, and the availability of nutrients or toxic substances.
References in periodicals archive ?
Concentrating on cell membrane receptors themselves, together with their immediate signal transducers, this introductory text on receptor pharmacology combines four major approaches in the study of receptors: molecular investigation of receptor structure; quantitative functional studies of agonists and antagonists; ligand binding; and signal transduction at the cell membrane.
Specific topics include a survey of immunology, superantigens, antigen presenting cells, cell mediated immune defense, cytokines as molecular mediators, interleukens, interferons as viral inhibitors and immune response mediators, interferon signaling through Janus kinases and signal transducers and activators of transcription, flow cytometry, immunoassays, genetic engineering of antibody molecules, autoantibodies and autoimmunity, synovial mast cells in inflammatory arthritis and the molecular and cell biology of HIV/AIDS.
Ligand's proprietary drug discovery and development programs are based on its leadership position in gene transcription technology, primarily related to Intracellular Receptors (IRs) and Signal Transducers and Activators of Transcription (STATs).
Janus kinases (JAK) are a small family of receptor-associated kinases, that together with signal transducers and activators of transcription (STAT), provide a rapid signalling pathway for cytokines.
is a La Jolla-based biopharmaceutical company that is developing small-molecule drugs that regulate hormone-activated intracellular receptors (IRs) and signal transducers and activators of transcription (STATs).
Ligand, in our view, has one of the most comprehensive programs in the pharmaceutical industry aimed at understanding and modulating the complex and tissue selective interactions of the dozens of intracellular receptors (IRs) and signal transducers and activators of transcription (STATs)," said Hurwitz.
founded in 1987, is a leader in gene transcription technology, particularly intracellular receptor (IR) technology and Signal Transducers and Activators of Transcription (STATs).
Ligand and SmithKline Beecham (SB) entered into a multi-year research collaboration to utilize Ligand's proprietary technology relating to Signal Transducers and Activators of Transcription (STATs) to discover and characterize small molecule, orally bioavailable drugs to control formation and the development of blood cells (hematopoiesis).
and Ligand's second gene transcription technology, Signal Transducers and Activators of Transcription (STATs) in commercial exploitation with Abbott Laboratories.

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