As a member of the signal transducer
and activator of transcription (STAT) family, STAT3 has received much attention during the past decade  It is involved in many processes such as immune responses, inflammation, and tumorigenesis.
Primers for real time-PCR analysis Gene category Gene name GenBank ID Primer Growth hormone Growth hormone receptor NM_176608 Forward signaling (GHR) Reverse Signal transducer
and NM_174617 Forward activator of Reverse transcription 5B (STAT5B) Insulin-like growth NM_001077828 Forward factor (IGF-1) Reverse Androgen receptor NM_001244127 Forward Reverse Myostatin NM_001001525 Forward Reverse Lipogenesis Fatty acid synthase NM_001012669 Forward (FASN) Reverse Fatty acid binding BT10868 Forward protein 4 (FABP4) Reverse Lipid Adipose triglyceride NM_001046005 Forward metabolism lipase (ATGL) Reverse Acyl-CoA synthetase NM_001076085.
The mechanism by which berberine modulates -germline transcript expression might be through regulating the phosphorylated IkBa level and the expressions of signal transducer
and activator of transcription-3 and T-box transcription factor TBX21.
The aim of this proposal, which combines structural biology and live cell imaging, is to understand the function and signalling consequences of the multivalent interactions between Hh signal transducer
proteins as well as their spatial and temporal regulation in the primary cilium.
Editor's note: FLLL32 reduced activation of the protein known as signal transducer
and activator of transcription 3 (STAT3), which is elevated in approximately 82% of head and neck cancers and has been associated with cisplatin resistance.
We assessed maximal leptin-mediated binding of the transcription factor signal transducer
and activator of transcription 3 (STAT3), and the response to high-fat feeding in lean leptin-resistant rats.
The oncology test panels will feature GLG's patented inhibitors of Signal Transducers
and Activators of Transcription 3 (STAT3), which are in preclinical development for a new generation of targeted therapies.
Concentrating on cell membrane receptors themselves, together with their immediate signal transducers
, this introductory text on receptor pharmacology combines four major approaches in the study of receptors: molecular investigation of receptor structure; quantitative functional studies of agonists and antagonists; ligand binding; and signal transduction at the cell membrane.
Specific topics include a survey of immunology, superantigens, antigen presenting cells, cell mediated immune defense, cytokines as molecular mediators, interleukens, interferons as viral inhibitors and immune response mediators, interferon signaling through Janus kinases and signal transducers
and activators of transcription, flow cytometry, immunoassays, genetic engineering of antibody molecules, autoantibodies and autoimmunity, synovial mast cells in inflammatory arthritis and the molecular and cell biology of HIV/AIDS.