Shwartzman phenomenon


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Shwartzman phenomenon

 [shwarts´man]
a local tissue reaction characterized by hemorrhagic necrosis due to an antigen-antibody reaction to certain bacterial substances. Its occurrence in humans is largely theoretical.

Shwartz·man phe·nom·e·non

(shwarts'măn),
that a rabbit injected intradermally with a small quantity of lipopolysaccharide (endotoxin) followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection.
See also: generalized Shwartzman phenomenon.
Synonym(s): Shwartzman reaction

Shwartz·man phe·nom·e·non

(shwarts'mahn fĕ-nom'ĕ-non)
A rabbit injected intradermally with a small quantity of lipopolysaccharide (endotoxin) followed by a second intravenous injection 24 hours later develops a hemorrhagic and necrotic lesion at the site of the first injection.
See also: generalized Shwartzman phenomenon

Shwartzman,

Gregory, Russian bacteriologist in U.S., 1896-1965.
generalized Shwartzman phenomenon - death occurs in an animal that has been injected with a primary injection of endotoxin-containing filtrate and secondary injection given intravenously 24 hours apart. Synonym(s): Sanarelli phenomenon; Sanarelli-Shwartzman phenomenon
Sanarelli-Shwartzman phenomenon - Synonym(s): generalized Shwartzman phenomenon
Shwartzman phenomenon - a rabbit injected intradermally with a small quantity of endotoxin followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection. Synonym(s): Shwartzman reaction
Shwartzman reaction - Synonym(s): Shwartzman phenomenon

Shwartzman phenomenon, Shwartzman reaction, Shwartzman-Sanarelli reaction

a reaction to a second dose of bacterial endotoxin. It may be a local tissue reaction characterized by thrombosis, infarction and hemorrhagic necrosis, or generalized with disseminated intravascular coagulation and bilateral renal cortical necrosis.