short tandem repeat

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A highly polymorphic segment of DNA composed of repetitive stretches of short sequences of 2–6 base pairs of DNA, which serve as genetic markers to track inheritance in families. Microsatellites include dinucleotides, trinucleotides and tetranucleotides, repeated in tandem arrays throughout a genome. The human genome has 50–100,000 microsatellite loci.

short tandem repeat (STR)

short repetitive DNA sequence. The repeat unit is generally 1–13 NUCLEOTIDES in length and the number of repeats varies in different individuals, usually from 5 to 20. The POLYMERASE CHAIN REACTION (PCR) can be used to determine the number of repeats at a LOCUS, by using PRIMERS that anneal either side of the STR, and analysing the size of the resulting PCR product after amplification. Useful for identification of individuals by DNA FINGERPRINTING.Also called microsatellite DNA
References in periodicals archive ?
Microsatellites, also known as simple sequence repeats (SSRs) or short tandem repeats (STRs), are highly polymorphic and codominant molecular markers that are based on simple repeated and frequent sequences common in eukaryotic genomes, which have proven to be an effective tool in genetic diversity and molecular ecology studies (Goldstein and Schloterer, 1999).
Detecting short tandem repeats from genome data: opening the software black box.
The findings were verified independently by identical experiments in each laboratory and were traced back to genetic differences between the two batches already at the time of purchase that were not detected in initial authenticity tests of short tandem repeats but only by comparative genomic hybridization.
According to Ahlstrom, the cards deliver an ideal solution for a wide range of applications including Polymerase chain reaction (PCR), real-time PCR and short tandem repeats (STR) analysis.
Microsatellite markers, also known as Short Tandem Repeats (STRs), are specific motif (2-6 bp) based repetitive DNA sequences widely spreading throughout the whole genome (Hammond et al.
Short tandem repeats (STRs) are easily typed, ubiquitous and polymorphic loci with high mutation rates.
Genotyping of biological samples for Short Tandem Repeats (STR) is now routinely performed in human identification and forensic laboratories.
Compared with short tandem repeats or SNPs, segmental duplications are relatively less polymorphic in the human genome.
Federal Bureau of Investigation (FBI) scans a DNA sample for at least 13 short tandem repeats (STRs).
A larger spectrum of intragenic short tandem repeats improves linkage analysis and localization of intragenic recombination detection in the dystrophin gene: an analysis of 93 families from Southern Italy.
leprae in 10 polymorphic loci short tandem repeats (STRs) was investigated in clinical specimens obtained from leprosy patients from geographically defined areas.
Detection of lymphocyte chimerism in skin and GI biopsy by amplification of short tandem repeats by PCR.

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