Sézary syndrome

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Related to Sezary syndrome: mycosis fungoides

Sézary syndrome

 [sa´zah-re]
a form of cutaneous T-cell lymphoma manifested by generalized exfoliative erythroderma, intense pruritus, peripheral lymphadenopathy, and abnormal hyperchromatic mononuclear cells in the skin, lymph nodes, and peripheral blood (Sézary cells).

Sé·za·ry syn·drome

(sā-zah-rē'),
exfoliative dermatitis with intense pruritus, resulting from cutaneous infiltration by atypical mononuclear cells (T lymphocytes with markedly convoluted or cerebriform nuclei) also found in the peripheral blood, and associated with alopecia, edema, and nail and pigmentary changes; a variant of mycosis fungoides.

Sé·za·ry syn·drome

(sā-zah-rē'),
exfoliative dermatitis with intense pruritus, resulting from cutaneous infiltration by atypical mononuclear cells (T lymphocytes with markedly convoluted or cerebriform nuclei) also found in the peripheral blood, and associated with alopecia, edema, and nail and pigmentary changes; a variant of mycosis fungoides.

Sézary syndrome

[sāzärē′]
Etymology: A. Sézary, French dermatologist, 1880-1956
a condition of generalized exfoliating erythroderma, lymphadenopathy, and abnormal circulating T cells. The patient experiences pruritus, alopecia, edema, and nail and pigment changes.
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Sézary syndrome

Sezary syndrome

Mycosis fungoides, see there.

Sé·za·ry syn·drome

(sā-zah-rē' sindrōm)
Exfoliative dermatitis with intense pruritus, resulting from cutaneous infiltration by atypical mononuclear cells also found in the peripheral blood, and associated with alopecia, edema, and nail and pigmentary changes; a variant of mycosis fungoides.

Sezary syndrome

A rare condition featuring a malignant spread of excessive numbers of abnormal T LYMPHOCYTES in the blood, with enlarged lymph nodes and deposits in the skin, liver and spleen. There are red, scaly patches on the skin extending to form a widespread, itchy and flaking rash, hair loss and distortion of the nails. The condition is thought to be caused by a retrovirus, HTLV-I. Treatment is with anticancer drugs and RADIOTHERAPY. (Albert Sezary, 1880–1956, French physician).

Sézary syndrome

A leukemic phase of CTCL that develops in some patients, characterized by the appearance of malignant T cells in the peripheral blood and sometimes in the lymph nodes. The syndrome is named for Alfred Sézary (1880–1956), a French dermatologist.

Bouvrain,

Y., French physician.
Sézary-Bouvrain syndrome - Synonym(s): Sézary syndrome

Sézary,

Albert, French dermatologist, 1880-1956.
Sézary-Bouvrain syndrome - Synonym(s): Sézary syndrome
Sézary cell - an atypical T lymphocyte seen in the peripheral blood in Sézary syndrome.
Sézary erythroderma - Synonym(s): Sézary syndrome; Sézary-Bovrain syndrome
Sézary syndrome - a variant of mycosis fungoides. Synonym(s): Sézary-Bouvrain syndrome; Sézary erythroderma

Sézary syndrome

an exfoliative erythroderma due to cutaneous infiltration of reticular lymphocytes, with alopecia, edema and hyperkeratosis; believed to be a variant of mycosis fungoides. This condition of humans is similar to the epidermotropic form of cutaneous lymphoma which occurs in dogs. The Sézary cell is a characteristic cerebriform lymphocyte which occurs in the dermis and blood of patients with Sézary syndrome. It has a distinctive markedly convoluted nuclear membrane.
References in periodicals archive ?
Long-term follow-up is needed for patients with MF and Sezary syndrome to ensure stability of their disease and to provide surveillance for possible secondary malignancies, especially other lymphomas and lung cancer (38).
A review of the Sezary Syndrome products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
CTCL is a group of diseases, including Mycosis Fungoides and Sezary syndrome, all constituting types of non-Hodgkin's lymphoma in which certain cells of the lymph system (T-cells) become cancerous and affect the skin.
Three patients (11%) with Sezary syndrome achieved a complete response and partial responses were observed in seven patients (26%).
CTCL, which includes sezary syndrome and mycosis fungoides, is a cancer of the lymph system that initially manifests as open lesions, tumors, or rashes on the skin.
SAHA was shown to reduce the tumor burden and improve pruritus in CTCL patients, especially those with erythroderma and Sezary Syndrome.