Sezary cell

Sé·za·ry cell

(sā-zah-rē'),
an atypical T lymphocyte seen in the peripheral blood in Sézary syndrome; it has a large convoluted nucleus and scanty cytoplasm containing PAS-positive vacuoles.

Sézary cell

A cell with a convoluted cerebriform nucleus and coarse chromatin pattern, which is said to resemble finger painting.

Sé·zar·y cell

(sā-zah-rē' sel)
An atypical mononuclear cell seen in the peripheral blood in Sézary syndrome; has a large, convoluted nucleus and scanty cytoplasm containing vacuoles that test positive with the periodic acid-Schiff stain.

Sézary,

Albert, French dermatologist, 1880-1956.
Sézary-Bouvrain syndrome - Synonym(s): Sézary syndrome
Sézary cell - an atypical T lymphocyte seen in the peripheral blood in Sézary syndrome.
Sézary erythroderma - Synonym(s): Sézary syndrome; Sézary-Bovrain syndrome
Sézary syndrome - a variant of mycosis fungoides. Synonym(s): Sézary-Bouvrain syndrome; Sézary erythroderma
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References in periodicals archive ?
Sezary cell leukaemia: a distinct T cell disorder or a variant form ofT prolymphocytic leukaemia?
Results from the multi-center dose-escalating Phase I CTCL trial, which treated 13 patients with intravenous forodesine hydrochloride, demonstrated that nine out of 13 patients showed improvement in skin and/or a pharmacodynamic response as measured by a decrease in the absolute Sezary cell numbers and/or the CD4/CD8 ratio.
Nine out of 13 patients had an improvement in skin and/or a pharmacodynamic response as measured by a decrease in the absolute Sezary cell numbers and/or the CD4/CD8 ratio.
Peripheral Sezary cell counts were documented on a 10-point scale; improvement of redness, itching and scale was noted during a 16-week trial period.
One patient with Sezary syndrome (an advanced hematological expression of CTCL) had a rapid and dramatic fall in blood Sezary cell (SC) count with apoptotic SCs visible following treatment with Targretin capsules.
Here she was responsible for QC/QA and staff training as well as performing bone marrow diffs, smears, and initial reading for Sezary cells and diagnostic differentials on the full spectrum of leukemia through to hemoglobinopathies.
1,2,4,5] Some plasma cells had markedly irregular nuclear contours, while others had distinct nuclear lobulation similar to those seen in neutrophilic bands and segmented forms, megakaryocytes, Sezary cells, or convoluted lymphoblastic lymphoma.
Identifying Sezary cells in the peripheral blood remains a dilemma for many clinicians.
We have previously demonstrated that butyrate and retinoids are capable of upregulating IL-2R expression on chronic lymphocytic leukemia cells and Sezary cells," said Francine M.