sex hormone-binding globulin


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sex hor·mone-bind·ing glob·u·lin (SHBG),

a plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

sex hor·mone-bind·ing glob·u·lin

(SHBG) (seks hōrmōn-bīnding globyū-lin)
Plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men.
Synonym(s): testosterone-estrogen-binding globulin.

sex hormone-binding globulin

A plasma glycoprotein that binds androgens or estrogens, leaving small concentrations of free hormones to circulate in the blood.
See also: globulin
References in periodicals archive ?
Cardiovascular risk factors in men: the role of gonadal steroids and sex hormone-binding globulin.
Associations of sex hormone-binding globulin and testosterone with diabetes among men and women (the Saku Diabetes study): a case control study.
Kahn, "Human sex hormone-binding globulin gene expression- multiple promoters and complex alternative splicing," BMC Molecular Biology, vol.
Sex hormone-binding globulin secretion by human hepatocarcinoma cells is increased by both estrogens and androgens.
The remainder binds tightly to sex hormone-binding globulin (SHBG, about 65%) or loosely to albumin (~30%).
Serum estradiol-binding profiless in postmenopausal women undergoing three common estrogen replacement therapies: associations with sex hormone-binding globulin.
If yes, continue evaluation, including assessment of at least two of three measures of total testosterone, free testosterone, or sex hormone-binding globulin.
Hyperthyroidism, increased levels of thyroid hormones lead to increased concentration of Sex Hormone-Binding Globulin (SHBG).
5-7) In adolescent girls, lifestyle modification alone can result in a 59% reduction in free androgen index with a 122% increase in sex hormone-binding globulin (SHBG).
Sex hormone-binding globulin (SHBG) [11] is a homodimeric protein that serves to transport sex steroids in circulation (1-3).
In this article you will learn of a critical blood marker of hormonal balance called sex hormone-binding globulin or SHBG.