sex hormone-binding globulin

(redirected from Sex hormone binding globulin)
Also found in: Acronyms, Wikipedia.

sex hor·mone-bind·ing glob·u·lin (SHBG),

a plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

sex hor·mone-bind·ing glob·u·lin

(SHBG) (seks hōrmōn-bīnding globyū-lin)
Plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men.
Synonym(s): testosterone-estrogen-binding globulin.

sex hormone-binding globulin

A plasma glycoprotein that binds androgens or estrogens, leaving small concentrations of free hormones to circulate in the blood.
See also: globulin
References in periodicals archive ?
Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal women.
1993) Differential effects of oral conjugated estrogens and transdermal estradiol on insulin-like growth factor 1, growth hormone and sex hormone binding globulin serum levels.
Sex hormone binding globulin in postmenopausal women: a predictor of osteoporosis superior to endogenous oestrogens.
Estrogen and androgen regulation of sex hormone binding globulin secretion by a human liver cell line.
Sex hormone binding globulin (SHBG) is a glycoprotein possessing high affinity binding for 17 beta-hydroxysteriod hormones such as testosterone and oestradiol.
Insulin resistance and high insulin blood levels, which accompany PCOS, contribute to hyperandrogenism by increasing production of ovarian androgen and decreasing the synthesis of sex hormone binding globulin.
Increased levels of [alpha]-subunit and serum sex hormone binding globulin are also suggestive of pituitary tumor rather than hormonal resistance.
When you give oral estrogen replacement, you cause an increase in a woman's sex hormone binding globulin (SHBG), which in turn decreases her serum levels of testosterone, said Dr.
This goes the same for nearly every chronic condition; changing the diet to a whole-foods base and increasing physical activity will assist in weight loss (thereby decreasing the amount of testosterone that is aromatized to estrogen) and will also serve to lower sex hormone binding globulin (SHBG).
Conversely, diabetes and the metabolic syndrome can be risk factors for hypogonadism through some similar but mostly distinct mechanisms, such as increased body weight; decreased sex hormone binding globulin levels; suppression of gonadotrophin release or Leydig cell testosterone production; cytokine-mediated inhibition of testicular steroid production; and increased aromatase activity contributing to relative estrogen excess.
Serum total testosterone concentrations vary in proportion to varied free testosterone concentrations and in proportion to varied sex hormone binding globulin (SHBG) concentrations.