sex hormone-binding globulin

(redirected from Sex hormone binding globulin)
Also found in: Acronyms, Wikipedia.

sex hor·mone-bind·ing glob·u·lin (SHBG),

a plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men; serum concentrations are increased in certain types of liver disease and in hyperthyroidism but are decreased with advancing age, by androgens, and in hypothyroidism.

sex hor·mone-bind·ing glob·u·lin

(SHBG) (seks hōrmōn-bīnding globyū-lin)
Plasma β-globulin, produced by the liver, which binds testosterone and, with a weaker affinity, estrogen; serum levels of SHBG in women are twice those found in men.
Synonym(s): testosterone-estrogen-binding globulin.

sex hormone-binding globulin

A plasma glycoprotein that binds androgens or estrogens, leaving small concentrations of free hormones to circulate in the blood.
See also: globulin
References in periodicals archive ?
Keywords: Homeostatic model assessment-Insulin resistance, Insulin resistance, Sex hormone binding globulin, Type 2 diabetes mellitus.
LNCaP cells were treated with ((a)(A)) 0,1, 25, and 100 nM testosterone (Te) in serum-free medium, ((a)(B)) 25 nM Sex Hormone Binding Globulin (SHBG) plus 0,1, 25, and 100 nM testosterone in serum-free medium, and ((a)(C)) 125 nM SHBG plus 0,1, 25, and 100 nM testosterone in serum-free medium.
Increased upper body and overall adiposity is associated with decreased sex hormone binding globulin in postmenopausal women.
Relationship between BMI, total testosterone, sex hormone binding globulin, leptin, insulin and insulin resistance in obese men.
Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA).
The Access Sex Hormone Binding Globulin (SHBG) assay is for use in the differential diagnosis of conditions of chronic or excessive androgenic activity.
424 OC: Osteocalcin, CTx: C-terminal telopeptide, Total T: Total testosterone, Total E2: Total estradiol, FreeT: Free testosterone, FreeE2: Free estradiol, BioT: Bioavailable testosterone, BioE2: Bioavailable estradiol, FAI: Free androgen index FEI: Free estrogen index SHBG: Sex hormone binding globulin Table 3.
The men in the study had their hormone levels measured for both chemical forms of testosterone and estrogen found in blood, when each is either unattached or circulating freely, and when each is attached to a separate protein, known as sex hormone binding globulin, or SHBG for short.
Patients with diabetes, cardiovascular, or urological diseases were excluded, as were those with abnormal levels of total testosterone or sex hormone binding globulin.
The US researchers measured women's levels of sex hormone binding globulin (SHBG), a protein that ties up testosterone and prevents it being used in the body.
There is a decrease in sex hormone binding globulin levels in PCOS with TZD use.
The pill curbs the hormone's production and also raise levels of sex hormone binding globulin (SHBG).