Sertoli cell


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Related to Sertoli cell: Leydig cell, Sertoli cell tumor

Sertoli cell

(sər-tō′lē, sĕr-)
n.
Any of the elongated, striated cells of the seminiferous tubules of the testis, to which spermatids attach for nourishment during spermatogenesis.

Sertoli cell

[sertō′lē]
Etymology: Enrico Sertoli, Italian histologist, 1842-1910; L, cella, storeroom
one of the supporting elongated cells of the seminiferous tubules of the testes. It functions to nourish the developing spermatocytes.

Sertoli cell

An elongated cell in the seminiferous tubules of the testis which secretes sex hormone-binding globulin and provides a micro-environment for developing sperm.

Sertoli cells secretions
• Anti-Müllerian hormone—Early foetal life.
• Inhibin and activins—Post-pubertal; regulate FSH secretion.
• Androgen binding protein—Concentrates testosterone in the seminiferous tubules, stimulating spermiogenesis.
• Oestradiol aromatase—Converts testosterone to 17 beta oestradiol for spermatogenesis.
• Glial cell-derived neurotrophic factor—Drives spermatogonial stem cell renewal during perinatal period.
• ERM transcription factor—Maintains spermatogonial stem cell in the adult testis.
• Transferrin—Iron ion delivery.

Sertoli cell

any of the elongated cells in the tubules of the testes to which the spermatids become attached; they provide support, protection and, apparently, nutrition until the spermatids are transformed into mature spermatozoa.

ovarian Sertoli cell tumor
Sertoli-Leydig tumor of an atopic ovary in a bitch, commonly associated with cystic endometrial hyperplasia.
testicular Sertoli cell tumor
occurs most commonly in dogs, particularly in retained testicles. Production of estrogen may cause feminization in which the dog is attractive to other males with reduced libido, feminine distribution of body fat, symmetrical alopecia, atrophy of the penis, increased size of the mammary glands and prepuce, and prostatic enlargement. Rarely there is depression of bone marrow activity with anemia, thrombocytopenia and granulocytopenia.
References in periodicals archive ?
Polycyclic aromatic hydrocarbon-induced cytotoxicity in cultured rat Sertoli cells involves differential apoptotic response.
Effects of vitamin C and E on PCB (Aroclor 1254) induced oxidative stress, androgen binding protein and lactate in rat Sertoli cells.
Cytokines, polarity proteins, and endosomal protein trafficking and signaling--The Sertoli cell blood-testis barrier system in vitro as a study model," Methods in Enzymology 534: 181-194.
FSH is a primary determinant of Sertoli cells and causes hyperplasia, proliferation and differentiation, however, IGF-I, vascular endothelial growth factor and transforming growth factor may play a role as a main determinant.
Rather, it is the amount of the SMAD3 protein in the Sertoli cell that is different in the immature, multiplying Sertoli cell compared to the mature, adult cell," said the researchers.
Both types of cells had a mitotic prophase, the spermatogonias appeared and each Sertoli cell appeared in primary and secondary spermatocytes.
Microdeletions in the more proximal regions (AZFa and AZFb) cause spermatogenic arrest and sertoli cell only (SCO) syndrome, whereas partial deletions in these regions and deletions in distal regions (AZFc and AZFd) cause variable phenotypes ranging from normal to oligozoospermia and azoospermia (4,5,7).
A decrease in the sertoli cell count and absence of the primary stages of the Spermatogenesis were noted.
All germ cell and Sertoli cell nucleoli present at stage VIII of the seminiferous epithelium cycle (SEC) were counted in 10 round or nearly-round seminiferous tubule cross-sections, chosen at random, for each animal.
The proband in this family suffered from another rare illness, ie, Sertoli cell only syndrome.
In vitro effect of FSH and testosterone on Sertoli cell nursing function in wall ligard.
Western blot analysis using anti- galectin-3 was carried out with HT-29 cells (Human Colon cancer cells), MSC-1 (mouse Sertoli cell line), ASC-17D (rat Sertoli cell line) and MA-10 cells (mouse Leydig cell line).