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serpin |
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serpin /ser·pin/ (ser´pin) any of a superfamily of inhibitors of serine proteinase, found in plasma and tissues; all are homologous single-chain glycoproteins targeting specific serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. serpin [ser′pin] any of a superfamily of inhibitors of serine endopeptidase (serine proteinase), found in plasma and tissue. All are similarly structured single-chain glycoproteins, although each one acts specifically on particular endopeptidases. Among their targets are serine proteinases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, alpha2-antiplasmin, C1 inhibitor, and plasminogen activator inhibitor 1. Also called serine protease inhibitor or serine proteinase inhibitor. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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