serotonin syndrome

(redirected from Serotonin storm)

serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

an aggregation of symptoms resulting from elevated levels of serotonin, usually due to ingestion of two or more drugs (for example, MAOIs, SSRIs) that interfere with serotonin metabolism at different points. Symptoms occur on a spectrum and may include agitation, confusion, diaphoresis, diarrhea, fever, shivering, tremor, myoclonus, rigidity, trismus, opisthonus, seizures, drowsiness, hallucinations, and coma. Autonomic signs include abdominal pain, diarrhea, flushing, hypertension, mydriasis, salivation, tachycardia, and tachypnea. Hyperthermia is common. More advanced cases may include patients suffering DIC, rhabdomyolysis, renal failure, respiratory failure, and ARDS.

serotonin syndrome

Psychiatry A potentially life threatening condition caused by combined therapy with MAOIs and selective serotonin reuptake inhibitor–SSRI, antidepressants–Prozac, Zoloft, Paxil, Luvox, Wellbutrin–bupropion, tryptophan or tricyclic antidepressants, which abruptly ↑ serotonin resulting in neuromuscular, autonomic, and behavioral changes due to ↑ CNS serotonin activity Clinical Confusion, diaphoresis, ataxia, excitement, hyperthermia, hyperreflexia, myoclonus, hypotension, tremor Complications DIC, rhabdomyolisis, cardiovascular compromise Management D/C offending drug, support vital functions, dantrolene–muscle relaxant, Periactin–cyproheptadine–antihistamine, serotonin antagonist. See MAOI, SSRI.

serotonin syndrome

A potentially dangerous reaction to drug administration or drug interactions that involve excessive serotonergic agonism. The effects range from mild to life-threatening and include AKATHISIA, tremor, altered mental states, agitation, clonus, muscular hypertonicity, hyperthermia and death. Many drugs have been found to be implicated and these are not limited to the selective serotonin re-uptake inhibitors.

Serotonin syndrome

A group of symptoms caused by severely elevated serotonin levels in the body.
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