serotonin antagonist


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Related to serotonin antagonist: Serotonin syndrome, Dopamine antagonist

serotonin antagonist

Any of a class of medications used to treat or prevent nausea and vomiting. Examples are ondansetron (Zofran) and granisetron (Kytril).
See also: antagonist
References in periodicals archive ?
There are some differences in metabolism and receptor specificities among the different serotonin antagonists.
Serotonin antagonists were developed through modifications in the antiemetic metoclopramide, and work by selectively blocking the serotonin receptors both centrally - in the hypothalamus, the chemoreceptor trigger zone and the cerebral cortex and peripherally in the enterochromaffin cells of the intestinal mucosa.
Comparison of the effects of the benzodiazepine midazolam and three serotonin antagonists on a consummatory conflict paradigm.
12,13) Likewise, the serotonin antagonists nefazodone and trazodone have been shown to reduce the frequency of PTSD nightmares, as well as improve overall sleep quality.
Although the animal model suggests that serotonin antagonists should be a useful treatment, this has not been tested in humans.
Cesamet can be effective in people who don't respond to drugs like ondansetron and other serotonin antagonists, said oncologist Paul Daeninck of the University of Manitoba, Winnipeg.

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