occult primary malignancy

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occult primary malignancy

Occult cancer, unknown primary A malignancy of unknown 1º site or origin that is symptomless, which first manifests itself as metastases or secondary–paraneoplastic phenomena, and usually has a poor prognosis; OPMs are problematic as appropriate therapy requires that the primary malignancy be eradicated, and many remain obscure despite aggressive diagnostic work-up; certain malignancies metastasize to certain sites with greater than expected frequency; in OPMs affecting the brain, the primary arises in the lungs in up to 85% Treatment Up to 30% of Pts with metastases from an occult primary adenoCA may respond to chemotherapy–mitomycin C, adriamycin, vincristine; poor response is more common in ♂ and in Pts with liver and/or infradiaphragmatic metastases
Occult primary malignancies
Bone Breast, bronchus, prostate, thyroid, kidney
CNS Breast, bronchus, kidney, colon
Head & neck Oropharynx, nasopharynx–most are squamous cell carcinoma;  also adenocarcinoma, melanoma, rhabdomyosarcoma, oat cell, salivary  gland, thyroid carcinomas
Liver CA of stomach, colon, breast, pancreas, or bronchus
Lung Breast, colon, kidney, melanoma, sarcoma, stomach, testis, thyroid
Lymph nodes
• Cervix  Naso– and oropharynx, thyroid, larynx, lymphoma
• Supraclavicular  Bronchi, breast, stomach, esophagus, pancreas, colorectal,
lymphoma
• Axillary  Breast, melanoma, lymphoma
• Inguinal  Urogenital tract, anus, melanoma, lymphoma
Ovary Stomach, colon
Serosal surfaces Bronchi, breast, ovary, lymphoma
Skin Melanoma, breast, bronchus, stomach, kidney  
References in periodicals archive ?
The coelomic cavity contained a small to moderate amount of reddish fluid, and the visceral and parietal serosal surfaces were multifocally opaque, whitish, edematous, and partially adherent to each other.
Familial Mediterranean fever (FMF) is a hereditary disorder characterized by repeated attacks of inflammation of serosal surfaces concomitant with fever.
The omentum, peritoneal surfaces of the right hemidiaphragm, posterior cul-de-sac and right upper quadrant, and serosal surfaces of the uterus, bladder, and rectosigmoid colon had serous carcinoma characterized by highly cellular complex papillae, slitlike glandular spaces, and occasional cribriform glands.
Mesothelioma is a neoplasm of the serosal surfaces.
The bas-relief sign represents the visualization of both the luminal and serosal surfaces of the bowel wall due to the accumulation of free intraperitoneal gas between bowel loops (Figure 37).
Thus, talc, long known to cause foreign-body granulomatous reactions when applied to serosal surfaces and similar granulomatous reactions in the lungs when inhaled over prolonged periods, also produces foreign-body granulomas when injected intravenously as part of a dissolved oral medication.
5 cm) were found at exploratory laparotomy involving the serosal surfaces of the uterus, fallopian tubes, and ovaries.
At postmortem examination, a chronic, fibrosing, coelomitis was present and affected the serosal surfaces of tissues nearest the perforation, including the proventriculus and the ventriculus.
The most common tumors of serosal surfaces are metastatic carcinomas, followed in incidence by malignant mesothelioma (MM).
Malignant mesothelioma is a neoplasm arising from the mesothelial cells of the serosal surfaces of the pleura and peritoneum.
5cm with faeces in the lumen, and microscopic findings of active inflammation in transmural sections, and schistosomal colonisation of the mucosal and serosal surfaces.
Furthermore, mesothelial hyperplasias are generally limited to the serosal surfaces, whereas invasion into the underlying stroma and dense cellularity of the stroma are useful indicators of malignant mesothelioma.