![]() 1,083,597,352 visitors served. |
|
![]() Dictionary/ thesaurus | ![]() Medical dictionary | ![]() Legal dictionary | ![]() Financial dictionary | ![]() Acronyms | ![]() Idioms | ![]() Encyclopedia | ![]() Wikipedia encyclopedia | ? |
Seroquel |
Also found in: Wikipedia | 0.02 sec. |
quetiapine fumarate Seroquel Pharmacologic class: Dibenzothiazepine derivative Therapeutic class: Atypical antipsychotic Pregnancy risk category C FDA Boxed Warning• Elderly patients with dementia-related psychosis are at increased risk for death. Over course of 10-week controlled trial, death rate in drug-treated patients was about 4.5%, compared to about 2.6% in placebo group. Although causes of death varied, most appeared to be cardiovascular or infectious. Don't give drug to patients with dementia-related psychosis. ActionUnknown. Antipsychotic effects may occur through antagonism of dopamine D2 and serotonin 5-HT2 receptors. Other effects may result partly from antagonism of other receptors, such as histamine H1 and alpha1-adrenergic receptors. AvailabilityTablets: 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, 400 mg ⊘ Indications and dosages ➣ Schizophrenia Adults: Initially, 25 mg P.O. b.i.d., increased by 25 to 50 mg given two to three times daily as tolerated over 3 days, up to 300 to 400 mg/day in two to three divided doses by day 4 (not to exceed 800 mg/day) ➣ Acute manic episodes associated with bipolar I disorder Adults: 100 mg on day 1, 200 mg on day 2, 300 mg on day 3, 400 mg on day 4, up to 600 mg on day 5, and up to 800 mg on day 6. Maximum daily dosage is 800 mg. May be given as monotherapy or as adjunctive therapy with lithium or divalproex. ➣ Depression associated with bipolar disorder Adults: Day 1, 50 mg P.O.; day 2, 100 mg P.O. ; day 3, 200 mg P.O.; day 4, 300 mg P.O. Dosage adjustment• Hepatic impairment Off-label uses• Bipolar disorder Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Give with or without food.
Adverse reactionsCNS: dizziness, sedation, cognitive impairment, extrapyramidal symptoms, tardive dyskinesia, neuroleptic malignant syndrome, seizures CV: palpitations, peripheral edema, orthostatic hypotension EENT: ear pain, rhinitis, pharyngitis GI: constipation, dyspepsia, dry mouth, anorexia Hematologic: leukopenia Respiratory: cough, dyspnea Skin: diaphoresis Other: weight gain, flulike symptoms InteractionsDrug-drug. Antihistamines, opioids, sedative-hypnotics, other CNS depressants: additive CNS depression Antihypertensives: increased risk of hypotension Barbiturates, carbamazepine, corticosteroids, phenytoin, rifampin, thioridazine: increased clearance and decreased efficacy of quetiapine Dopamine agonists, levodopa: antagonism of these drugs' effects Erythromycin, fluconazole, itraconazole, ketoconazole, other CYP450-3A4 inhibitors: increased quetiapine effects Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase: asymptomatic elevations Total cholesterol, triglycerides: increased levels Urine tricyclic antidepressant assay: false-positive screen White blood cells: decreased count Drug-behaviors. Alcohol use: increased CNS effects Patient monitoring☞ Monitor neurologic status, especially for signs and symptoms of tardive dyskinesia or neuroleptic malignant syndrome. Patient teaching• Tell patient he can take with or without food. Seroquel® Quetiapine, see there How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
|
? Mentioned in |
|---|
| Free Tools: |
For surfers:
Browser extension |
Word of the Day |
Help
For webmasters: Free content | Linking | Lookup box | Double-click lookup | Partner with us |
|
|---|