serine protease inhibitor


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inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

serine protease inhibitor, serine proteinase inhibitor

See serpin.

serine protease inhibitor

Abbreviation: serpin
Any of the compounds that inhibit platelet function and coagulation. Serpins have been used to reduce deposition of microemboli in cases of disseminated intravascular coagulation associated with sepsis.
See also: inhibitor
References in periodicals archive ?
In addition, the Company has filed an IND for its serine protease inhibitor program designed to inhibit activation of the complement pathway.
Serine protease inhibitors have wide applications in diverse fields such as inflammation, reperfusion injury and stroke.
Serine protease inhibitors are the best-known and most characterized inhibitors (Laskowski and Qasim, 2000).
This ruling clearly validates our joint venture's proprietary position for the use of serine protease inhibitors such as AAT for the treatment of inflammatory skin diseases, and gives additional impetus to our clinical trial program in Europe", said Pierre Laurin, ProMetic's Chairman and CEO.
Corvas' preclinical pipeline includes protease activated cancer therapies and serine protease inhibitors that also are expected to enhance Dendreon's efforts to establish itself as a leading developer of cancer therapeutics.
and 2 issued European patents that cover the use of a number of serine protease inhibitors in these clinical indications, and has developed a proprietary production system for the manufacture of potentially unlimited supplies of recombinant AAT from genetically engineered yeast cells.
He is well known for his innovative work in structure-based drug design and development of novel serine protease inhibitors, and has co-authored over 130 publications and patents.
Patent and Trademark Office recently issued six patents covering compositions that are useful as serine protease inhibitors.
In April, Axys announced the publication of a paper in the Journal of Molecular Biology describing the basis of a new technology for designing competitive and fully reversible serine protease inhibitors.
Discovery of oral serine protease inhibitors using proprietary drug design and combinatorial chemistry approaches is a key strength at Corvas.
The series of issued patents and pending applications provides broad protection for the composition of Lexin's serine protease inhibitors, methods of production and DNA sequences.
5,693,515, entitled "Metal Complexed Serine Protease Inhibitors," filed by Arris in May 1995, encompasses technology relating to methods useful in research for the discovery of novel protease inhibitors, for identifying structural activity relationships of protease inhibitors, for screening molecules against specific enzyme targets and for developing potent, selective small molecule protease inhibitors that have the potential to treat diseases associated with protease activity.

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