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passage
(redirected from Serial passage)

   Also found in: Dictionary/thesaurus, Legal, Encyclopedia, Wikipedia 0.01 sec.
pas·sage (psj)
n.
1. A movement from one place to another.
2. The process of passing from one condition or stage to another.
3. A path, channel, or duct through, over, or along which something may pass.
4. An act of emptying, as of the bowels.
5. The process of passing or maintaining a group of microorganisms or cells through a series of hosts or cultures.

passage
[pas′ij]
1 an opening, channel, route, or gap.
2 the movement of something from one place to another, as in evacuation of the bowels.

passage
introduction followed by recovery of an infectious agent in an experimental animal or culture medium.

blind passage
passage of an infectious agent through an experimental animal or medium without there being any evidence, clinical or cultural, that the agent is present.
serial passage
repeated passage through a series of experimental animals or media, often with the objective of altering the virulence of the agent or adapting it to grow better.


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Further studies, such as continuous serial passages and neutralization assay, are needed to determine the final activity of the virus in RD cells, as well as in other cells such as Vero and HeLa, because several species of picornaviruses have been identified as causing persistent infections in these cells in vitro (6-10).
More particularly, this invention is directed to the development of live virus vaccines against the parainfluenza group of agents following serial passage in chick embryo tissue culture, or human diploid lung fibroblasts.
The serial passage data showed extinction of the virus after 15 serial passages in the laboratory.
 
 
 
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