Senile plaques


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Senile plaques

Abnormal structures, composed of parts of nerve cells surrounding protein deposits, found in the brains of people with Alzheimer's disease.
Mentioned in: Dementia
References in periodicals archive ?
Alzheimer's patients show an accumulation of these senile plaques, which are made of a sticky substance called amyloid and are thought to kill brain cells, causing irreversible memory loss and personality changes.
Since many of the above-described findings can occur in non-demented elderly patients, an accurate pathologic diagnosis of AD requires information regarding the age and clinical history of the patient as well as an evaluation of the number and distribution of senile plaques and neurofibrillary tangles.
Today, he says, it's most likely that there are two primary causes of dementia: an Alzheimer's disease type "pathology," represented by the neurofibrillary tangles and senile plaques of the disease, and vascular dementia, resulting from significant changes in blood vessels in the brain.
The LI-COR Odyssey(R) Infrared Imaging System is being used as a detection platform for non-invasive screening of senile plaques in mice.
Clumps of large, sticky proteins forming senile plaques have been observed in the brains of people with Alzheimer disease ever since neurologist Alois Alzheimer first described the disorder nearly a century ago.
Another program targets spherons, tiny balls of proteins found in the human brain, which Nymox researchers believe are a major source of senile plaques, a hallmark of the disease.
TORONTO -- The [beta]-amyloid senile plaques and neurofibrillary tangles that are definitive for a diagnosis of Alzheimer's disease can now be identified without the need for brain biopsy specimen.
The PET image shows high densities of [beta]-amyloid senile plaques and neurofibrillary tangles in the hippocampal region.
Although senile plaques represent a defining hallmark of Alzheimer's disease (AD) brains their role in disease pathophysiology remains unclear.
HLA-DR immunostains showed microglia in the senile plaques of 3 DS patients.
The computer, which fills the space of two basketball courts, will be put to many uses, one of which is to analyze the formation of senile plaques in the brains of patients with Alzheimer's disease.
In 1984, researchers discovered that these senile plaques consist of a central core of beta amyloid protein, surrounded by a cluster of abnormal nerve cells clogged with twisted fibers called neurofibrillary tangles.