selective serotonin reuptake inhibitor

(redirected from Selective serotonin re-uptake inhibitor)
Also found in: Dictionary.

inhibitor

 [in-hib´ĭ-tor]
1. any substance that interferes with a chemical reaction, growth, or other biologic activity.
2. a chemical substance that inhibits or checks the action of a tissue organizer or the growth of microorganisms.
3. an effector that reduces the catalytic activity of an enzyme.
ACE i's (angiotensin-converting enzyme i's) see angiotensin-converting enzyme inhibitors.
angiogenesis inhibitor a group of drugs that prevent growth of new blood vessels into a solid tumor.
aromatase i's a class of drugs that inhibit aromatase activity and thus block production of estrogens; used to treat breast cancer and endometriosis.
C1 inhibitor (C1 INH) a member of the serpin group, an inhibitor of C1, the initial component activated in the classical complement pathway. Deficiency of or defect in the protein causes hereditary angioedema.
carbonic anhydrase inhibitor an agent that inhibits the enzyme carbonic anhydrase; used in treatment of glaucoma and sometimes for epilepsy, familial periodic paralysis, acute mountain sickness, and kidney stones of uric acid.
cholinesterase inhibitor anticholinesterase.
COX-2 i's (cyclooxygenase-2 i's) a group of nonsteroidal antiinflammatory drugs that act by inhibiting cyclooxygenase-2 activity; they have fewer gastrointestinal side effects than other NSAIDs. Two members of the group are celecoxib and rofecoxib.
gastric acid pump inhibitor an agent that inhibits gastric acid secretion by blocking the action of H+,K+-ATPase at the secretory surface of gastric parietal cells; called also proton pump i.
HIV protease inhibitor any of a group of antiretroviral drugs active against the human immunodeficiency virus; they prevent protease-mediated cleavage of viral polyproteins, causing production of immature viral particles that are noninfective. Examples include indinavir sulfate, nelfinavir mesylate, ritonavir, and saquinavir.
HMG-CoA reductase i's a group of drugs that competitively inhibit the enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis, and are used to lower plasma lipoprotein levels in the treatment of hyperlipoproteinemia. Called also statins.
membrane inhibitor of reactive lysis (MIRL) protectin.
monoamine oxidase inhibitor any of a group of drugs that inhibit the action of monoamine oxidase, the enzyme that breaks down norepinephrine and serotonin, prescribed for their antidepressant action; the most widely used ones are isocarboxazid, phenelzine, and tranylcypromine. They are also used in the prevention of migraine.
α2-plasmin inhibitor α2-antiplasmin.
plasminogen activator inhibitor (PAI) any of several regulators of the fibrinolytic system that act by binding to and inhibiting free plasminogen activator. Their concentration in plasma is normally low, but is altered in some disturbances of bodily hemostasis. PAI-1 is an important fast-reacting inhibitor of t-plasminogen activator and u-plasminogen activator. Its synthesis, activity, and release are highly regulated; elevated levels of it have been described in a number of disease states. PAI-2 is a normally minor inhibitor that greatly increases in concentration during pregnancy and in certain disorders. PAI-3 is protein C inhibitor.
platelet inhibitor any of a group of agents that inhibit the clotting activity of platelets; the most common ones are aspirin and dipyridamole. See also antiplatelet therapy.
protease inhibitor
1. a substance that blocks activity of endopeptidase (protease), such as in a virus.
protein C inhibitor the primary inhibitor of activated anticoagulant protein C; it is a glycoprotein of the serpin family of proteinase inhibitors and also inhibits several other proteins involved in coagulation (thrombin, kallikrein, and coagulation factors X and XI) and urokinase. Called also plasminogen activator inhibitor 3.
proton pump inhibitor gastric acid pump i.
reverse transcriptase inhibitor a substance that blocks activity of the reverse transcriptase of a retrovirus and is used as an antiretroviral agent. Some are nucleosides or nucleoside analogues, and those that are not are therefore often called non-nucleoside reverse transcriptase inhibitors.
selective serotonin reuptake inhibitor (SSRI) any of a group of drugs that inhibit the inactivation of serotonin by blocking its absorption in the central nervous system; used as antidepressants and in the treatment of obsessive-compulsive disorder and panic disorder.
serine protease inhibitor (serine proteinase inhibitor) serpin.
topoisomerase i's a class of antineoplastic agents that interfere with the arrangement of DNA in cells.

selective serotonin reuptake inhibitor

a class of chemical compounds that selectively, to varying degrees, inhibit the reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.

selective serotonin reuptake inhibitor

n.
An SSRI.

selective serotonin reuptake inhibitor (SSRI)

an antidepressant drug that blocks reuptake of serotonin without blocking reuptake of other biogenic amines such as norepinephrine and dopamine. Advantages over tricyclic antidepressant drugs include fewer anticholinergic side effects (dry mouth, blurred vision, urinary retention) and fewer antihistaminic side effects (sedation, weight gain).

selective serotonin reuptake inhibitor

Serotonin-selective-reuptake inhibitor, see there.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-ŭp'tāk in-hib'i-tŏr)
A class of drugs that selectively prevent the reuptake of serotonin and are used for the treatment of depression, e.g., fluoxetine, sertraline.

Selective serotonin reuptake inhibitor (SSRI)

A class of antidepressants that work by blocking the reabsorption of serotonin in the brain, raising the levels of serotonin. SSRIs include Prozac, Zoloft, and Paxil.

se·lec·tive ser·o·to·nin re·up·take in·hib·i·tor

(SSRI) (sĕ-lek'tiv ser'ŏ-tō'nin rē-up'tāk in-hib'i-tŏr)
Class of chemical compounds that selectively, to varying degrees, inhibit reuptake of serotonin by presynaptic neurons and are posited to exert their antidepressant effect by this mechanism.
References in periodicals archive ?
True (A) or false (B)--click on the correct answer: The selective serotonin re-uptake inhibitor antidepressants paroxetine and fluoxetine interfere with the metabolism of tamoxifen, markedly reducing its benefits.
For the women who didn't initially get well with IPT alone, the researchers offered a selective serotonin re-uptake inhibitor (SSRI), usually fluoxetine if tolerated.
Selective serotonin re-uptake inhibitor use in primary care: a five-year naturalistic study.
Urinary excretion of serotonin in depressed individuals significantly increased after antidepressant treatment by 5-hydroxytryptophan and/or selective serotonin re-uptake inhibitor (p < 0.
The DEP1 pathway is independent of the pathway used by the dominant class of drugs currently used to treat depression, known as Selective Serotonin Re-uptake Inhibitors (SSRIs).
What are Selective Serotonin Re-uptake Inhibitors (SSRIs)?
And, according to the Department of Health, there were over 12 million prescriptions dispensed for Selective Serotonin Re-uptake Inhibitors (SSRIs) - the new generation of antidepressants including Prozac and Seroxat - in 2001*.
Houghton pointed out that cataplexy is currently treated with anti-depressants, either selective serotonin re-uptake inhibitors, such as Prozac(R), or tricyclic anti-depressants.
Although it said young adults should be closely monitored if prescribed, the Committee on Safety of Medicines, which carried out the safety review, could find no clear increased risk of suicide associated with Seroxat and other selective serotonin re-uptake inhibitors (SSRIs) than with other anti-depressants.
However, a paradoxical claim was made against some antidepressants that came to the American market in the past fifteen years, alleging that selective serotonin re-uptake inhibitors (SSRIs) increase suicidal thoughts and possibly precipitate suicide attempts.
She is now warning others of the dangers of becoming addicted to prescription drugs such as the new anti-depressants Selective Serotonin Re-uptake Inhibitors (SSRIs) saying the side effects may not be known until it is too late.
They have a specific anti- phobic action on the brain, and some of the most successful are Selective Serotonin Re-Uptake Inhibitors which include Prozac and Seroxat.

Full browser ?