selective estrogen receptor modulator

(redirected from Selective estrogen-receptor modulator)
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modulator

 [mod´u-la″ter]
a specific inductor or agent that brings out characteristics peculiar to a definite region.
selective estrogen receptor modulator (SERM) an agent that activates some estrogen receptors but not others, thereby having estrogenlike effects on target tissues (such as bone) without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator (SERM),

pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

selective estrogen receptor modulator

n.
Abbr. SERM Any of a group of nonsteroidal drugs, such as raloxifene and tamoxifen, that bind to estrogen receptors and act in some cases as estrogen agonists and in others as estrogen antagonists.

selective estrogen receptor modulator (SERM)

an agent that activates some estrogen receptors but not others, thereby having estrogen-like effects on target tissues without affecting other tissues that have estrogen receptors.

selective estrogen receptor modulator

Designer estrogen, SERM Therapeutics A drug–eg, idoxifene, raloxifene–Evista®, which, like estrogen, prevents bone loss and ↓ cholesterol but, unlike estrogen, does not stimulate the endometrium and breast and thus does not ↑ risk of breast and endometrial CA. See Estrogen receptor, Raloxifene.

se·lec·tive es·tro·gen re·cep·tor mod·u·la·tor

(SERM) (sĕ-lek'tiv es'trŏ-jen rĕ-sep'tŏr mod'yū-lā'tŏr)
Pharmaceutical agent with selective estrogen receptor affinity; current preparations have a primary effect on bone and cardiovascular tissues and less effect on endometrial, genital, and breast tissues.

Selective estrogen receptor modulator

A hormonal preparation that offers the beneficial effects of hormone replacement therapy without the increased risk of breast and uterine cancer associated with HRT.
Mentioned in: Osteoporosis
References in periodicals archive ?
Ospemifene (OSP), a selective estrogen-receptor modulator (SERM) - also referred to as a nonsteroidal estrogen-receptor agonist/antagonist - is distinct from other SERMs because its estrogenic activity occurs on the vaginal epithelium, "but not on the endometrium," said Dr.
The selective estrogen-receptor modulator raloxifene doesn't appear to improve cognitive function in postmenopausal women, but it may delay cognitive decline, reported Dr.
Options include the selective estrogen-receptor modulators tamoxifen and raloxifene and the newer aromatase inhibitors, but the choice is not clear-cut.
Selective estrogen-receptor modulators are a good alternative for patients who aren't good candidates for estrogen, such as breast cancer survivors, she noted.
With all the therapeutic interventions currently available, such as calcium, vitamin D, weight-bearing exercises, bisphosphonates, calcitonins, selective estrogen-receptor modulators, and even estrogens, there is little reason for a woman under the care of any physician to become a victim of this osteoporosis.

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