In 1992, however, several deaths among liver patients and patients taking Seldane
at the same time they were using ketoconazole or erythromycin caused the FDA and the drug company to warn doctors, pharmacists, and patients of the potential danger of taking Seldane
at the same time as these other two drugs.
Among the drugs that grapefruit is known to affect: calcium-channel blockers like Procardia or Adalat, antihistamines like Seldane
, immunosuppressants like cyclosporine, short-acting sedatives like Halcion, and estrogens like Estinyl.
Antihistamines (Combination, cold/hay fever products with decongestants) -- Chlor-trimeton (Ornade, Isochlor), Dimetane (Dimetapp), Benadryl, Tavist, Ambodryl, Clistin, Decapryn, Polaramine, Forhistal, Actidil (Actifed), PBZ, Histadyl, Tacaryl, Phenergan, Temaril, Atarax/Vistaril, Optimine, Periactin, Seldane
Drug companies are expected to ask the FDA to switch an additional 70 or so drugs, including the popular sinus medication Seldane
and a number of ulcer drugs, within the next few years.
Cold, cough, and asthma drugs which have side effects simulating dementia: Seldane
His lab was the first to identify the hERG potassium channel as the unintended target for the cardiotoxic effects of Seldane
and Propulsid, both of which were subsequently withdrawn from the market.
ChanTest scientists were the first to prove hERG as the target for adverse cardiac events linked to non-cardiac drugs: Seldane
(terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and ChanTest pioneered the development of functional, cell-based ion channel testing as a means to predict cardiac side effects produced by non-cardiac drugs.
Other brand names on the list include Histafen Terfinax, Seldane
, Terfenor and Terfex.
Allergy sufferers who have depended on Seldane
to fight off sneezing, watery eyes and runny nose will have to turn to another medicine soon if the government succeeds in pulling the drug off the market.
The antihistamine Seldane
and the commonly prescribed antibiotic erythromycin can have serious effects when prescribed together.
But FDA warnings about other potentially life-threatening interactions between drugs, such as those involving nonsedating antihistamines such as Seldane
, have failed to stem the occurrence of preventable adverse events.
Chlor-trimeton (Ornade, Isochlor) Dimetane (Dimetapp), Benadryl, Tavist, Ambodryl, Clistin, Decapryn, Polaramine, Forhistal, Actidil (Actifed), PBZ, Histadyl, Tacaryl, Phenergan, Temaril, Atarax/Vistaril, Optimine, Periactin, Seldane
, Hismanal, Claritin