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A non-sedating antihistamine used for allergies and viral upper respiratory tract infections. It is available in Canada, the UK, and in some other countries by prescription, but was withdrawn from US market due to cardiotoxicity.

Adverse effects
Arrhythmias (e.g., torsades de pointes, which may be due to delayed repolarisation with marked QT prolongation) and bizarre T-wave changes.


An antihistamine-decongestant–terfenadine + pseudoephedrine-HCl Countraindications CAD, HTN, liver disease, therapy with erythromycin, itraconazole, ketoconazole, MAOIs; withdrawn from the market in 1998
References in periodicals archive ?
A diagnostic for the CYP3A mutation might have helped HMR, the producer of Seldane, save a $600 million franchise.
and Pondimin are diet drugs, Duract is a pain medication; Seldane is an antihistamine; and Posicor is a hypertension treatment.
Given this precedent, it is possible that a court would find that the concomitant use of Seldane and erythromycin is foreseeable.
In February, the antihistamine, Seldane, was withdrawn by Hoechst Marion Roussell.
57) When popular allergy medication Seldane (Hoechst Marion Roussel) was removed from the market in 1997, other manufacturers raced to advertise their allergy medications to potential consumers who could no longer acquire Seldane.
Earlier this year, the Food and Drug Administration issued a warning about Seldane, the widely used antihistamine for allergies.
Terfenadine is sold under brand names including Triludan, Triludan Forte, Seldane, Terfenor, Aller-Eze Clear, and Boots Antihistamine Tablets.
Food and Drug Administration proposed a ban on the widely prescribed allergy drug Seldane because it can cause a rare, but fatal, heart rhythm when taken with other drugs.
Allergy sufferers rejoiced when Seldane appeared on the market -- the first antihistamine to relieve the sneezing, watery eyes, and runny noses of pollen allergy without making the user sleepy.
Among the drugs that grapefruit is known to affect: calcium-channel blockers like Procardia or Adalat, antihistamines like Seldane, immunosuppressants like cyclosporine, short-acting sedatives like Halcion, and estrogens like Estinyl.
Although the pharmaceutical industry has not rushed to advertise prescription drugs, there currently appears to be a growing willingness to reach consumers directly regarding the availability of new prescription medications such as Seldane and cosmetic pharmaceuticals such as Rogaine and Retin A (Alperstein and Peyrot, 1993).
Murray suggests replacements for such oft-prescribed pharmaceuticals as Seldane, Tagamet, and Zantac in Natural Alternatives to Over-the-Counter and Prescription Drugs (New York: William Morrow & Company, 1994)