minocycline hydrochloride

(redirected from Sebomin)

minocycline hydrochloride

Aknemin (UK), Dentomycin (UK), Dom-Minocycline (CA), Dynacin, Gen-Minocycline (CA), Minocin, Novo-Minocycline (CA), PMS-Minocycline (CA), Ratio-Minocycline (CA), Riva-Minocycline (CA), Sandoz Minocycline (CA), Sebomin (UK), Sebren (UK), Solodyn

Pharmacologic class: Tetracycline

Therapeutic class: Anti-infective

Pregnancy risk category D


Binds reversibly to 30S ribosome, inhibiting bacterial protein synthesis


Capsules: 50 mg, 75 mg, 100 mg

Capsules (pellet-filled): 50 mg, 100 mg

Microspheres (sustained-release): 1 mg

Suspension: 50 mg/5 ml

Tablets: 50 mg, 75 mg, 100 mg

Indications and dosages

Infections caused by susceptible organisms

Adults: Initially, 200 mg P.O. then 100 mg P.O. q 12 hours or 50 mg P.O. q 6 hours

Children ages 8 and older: 4 mg/kg P.O. followed by 2 mg/kg q 12 hours

Gonorrhea in penicillin-sensitive patients

Adults: Initially, 200 mg P.O., then 100 mg q 12 hours for at least 4 days

Uncomplicated gonococcal urethritis in men

Adults: 100 mg P.O. q 12 hours for 5 days


Adults: Initially, 200 mg P.O., then 100 mg q 12 hours for 10 to 15 days


Adults: 50 mg P.O. one to three times daily

Dosage adjustment

• Renal impairment


• Hypersensitivity to drug, its components, or tetracyclines


Use cautiously in:
• sulfite sensitivity, renal disease, hepatic impairment, nephrogenic diabetes insipidus
• cachectic or debilitated patients
• pregnant (last half of pregnancy) or breastfeeding patients
• children younger than age 8 (not recommended).


• Ask patient about sulfite sensitivity before giving.
• Give with 8 oz. of water, with or without food.
• Know that drug is used in penicillin-sensitive patients.

Adverse reactions

CNS: headache

CV: pericarditis

EENT: pharyngitis

GI: nausea, vomiting, diarrhea, oral candidiasis, stomatitis, mouth ulcers

GU: bladder or vaginal yeast infection

Metabolic: eosinophilia, hemolytic anemia, thrombocytopenia

Skin: photosensitivity, rash

Other: dental caries; dental infection; gingivitis; periodontitis; tooth disorder, pain, or discoloration; superinfection; hypersensitivity reactions including anaphylaxis


Drug-drug.Adsorbent antidiarrheals: decreased minocycline absorption

Antacids containing aluminum, calcium, or magnesium; calcium, iron, and magnesium supplements; sodium bicarbonate: decreased minocycline absorption

Cholestyramine, colestipol: decreased oral absorption of minocycline

Hormonal contraceptives: decreased contraceptive efficacy

Methoxyflurane: nephrotoxicity

Penicillin: interference with bactericidal action of penicillin

Sucralfate: blocked absorption of minocycline

Warfarin: increased anticoagulant effect

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, amylase, aspartate aminotransferase, bilirubin, blood urea nitrogen: increased levels

Hemoglobin, platelets, neutrophils, white blood cells: decreased levels

Urinary catecholamines: false elevation

Drug-food.Dairy products: decreased minocycline absorption

Drug-behaviors.Alcohol use: decreased antibiotic effect

Sun exposure: increased risk of photosensitivity reaction

Patient monitoring

• Assess patient's oral health closely for dental problems.
• Monitor patient for superinfection, especially oral, bladder, and vaginal yeast infections.
• Evaluate CBC and renal and liver function tests frequently.

Watch closely for hypersensitivity reactions, including anaphylaxis.

Patient teaching

• Tell patient he may take with or without food, followed by a full glass of water. Instruct him to space doses evenly over 24 hours and to take one dose 1 hour before bedtime.
• Advise patient not to take with antacids or iron, calcium, or magnesium products.

Instruct patient to immediately report fever, chills, skin rash, unusual bleeding or bruising, sore throat, or mouth pain or discomfort.
• Stress importance of good oral hygiene to minimize adverse oral and dental effects.
• Tell patient to complete entire course of therapy even after symptoms improve.

Caution patient not to use outdated minocycline because it may cause serious kidney disease.
• Inform female patient that drug may make hormonal contraceptives ineffective. Urge her to use barrier contraception.
• Tell pregnant patient that drug may stain fetus' teeth if taken during last half of pregnancy.
• Advise female patient to tell prescriber if she is breastfeeding.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above.

minocycline hydrochloride

a tetracycline antibiotic.
indications It is prescribed for infections caused by gram-positive and gram-negative bacteria, rickettsia, anthrax, and other microorganisms.
contraindications It must be used with caution in cases of renal or hepatic dysfunction. Known hypersensitivity to this or other tetracyclines prohibits its use.
adverse effects Among the more serious adverse effects are GI disturbances, phototoxicity, vestibular toxicity, potentially serious superinfections, and various allergic reactions. Use during pregnancy or in children younger than 8 years of age may result in discoloration of teeth.

minocycline hydrochloride

An antibiotic of the tetracycline class. It is used in dentistry to treat periodontal disease. Minocycline is applied after scaling and root debridement. The application reduces probing depths and periodontal pathogenic microorganisms.
References in periodicals archive ?
An inquest found he died 12 hours after a reaction to the drug Sebomin, which he was taking in an effort to cure his acne.
An inquest found that the 6ft schoolboy, of Rhydyfelin, near Pontypridd, died 12 hours after a reaction to the drug Sebomin - the first death of its kind in the world said Cardiff coroner Mary Hassell, who added the tragedy was "beyond a one-in-a-million occurrence".
Last week the inquest found that the schoolboy, from Rhydyfelin, near Pontypridd, died after a reaction to the drug Sebomin - the first death of its kind in the world, according to Cardiff coroner Mary Hassell.
Six-footer Shaun Jones, 14, was prescribed Sebomin - commonly given to spot sufferers - for "mild acne" across his back and shoulders.
Dr Stephen Jolles, consultant immunologist at the University Hospital of Wales, said it was possible either the colourings or the active ingredient in the Sebomin tablets Shaun took caused the reaction.
As the pills were unavailable, the chemist called Shaun's GP, who said he should take Sebomin instead.
But because the tablets were out of stock, he was given the alternative drug Sebomin.
When Shaun went to collect his medication, the Minocin was out of stock so pharmacist Lee Coombs gave him Sebomin, which has the same active ingredient.
The court was told the pharmacy had run out of his GP's prescribed pill Minocin, so they gave him an alternative but similar pill, Sebomin.
His findings were consistent with the theory that Shaundied from an acute reaction to minocycline hydrochloride, the active ingredient in both Sebomin and Minocin, he added.
Dr Stephen Jolles, consultant immunologist at UHW, said it was possible either the colourings or the active ingredient in the Sebomin tablets Shaun took caused the reaction.
They were out of stock at his pharmacy and he was given Sebomin instead after the chemist asked his doctor.