CXCL12

(redirected from Sdf1)
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CXCL12

A gene on chromosome 10q11.1 that encodes a stromal cell-derived alpha chemokine of the intercrine family which, once bound to its receptor, CXCR4, activates lymphocytes, an interaction that has been implicated in the metastasis of breast and other cancers.

Molecular pathology
CXCL12 mutations are associated with resistance to HIV-1 infections.
References in periodicals archive ?
Hence, a study was conducted among IDUs of northeastern India to understand the existence and magnitude of genetic variants encoding CCR5, CCR2, and SDF1 and their relationships with the prevalence of HIV infection among them.
Primers for the amplification of CCR5 (FP: 5' TTA AAA GCC AGG ACG GTC AC 3' and RP: 5' TGT AGG GAG CCC AGA AGA GA 3'), CCR2 (FP: 5' TTG TGG GCA ACA TGA TGG 3' and RP: 5' CTG TGA ATA ATT TGC AGA TTG C 3'), and SDF1 (FP: 5' AAG GCT TCT CTC TGT GGG ATG 3' and RP: 5' GAC AGT CGT GGA CAC ACA TGA T 3') were custom-synthesized from Integrated DNA Technologies (IDT), Inc.
Distribution of the wild type, heterozygous and homozygous mutations in the CCR2 and SDF1 genes in the study population are shown in Fig.
Table 2 shows the seroprevalence of HIV among IDUs with and without the CCR2 and SDF1 mutant genes.
On matching unsafe injection-practices, the rate of HIV seropositivity was observed to be almost equal in IDUs with and without CCR2 and SDF1 mutant genes.