Infections due to Scedosporium apiospermum and Scedosporium prolificans
in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome.
By the fourth hospital day, blood cultures showed yeast, with all six cultures subsequently positive for Scedosporium prolificans.
The genus Scedosporium consists of two medically important species: Scedosporium apiospermum (and its teleomorph or sexual state Pseudallescheria boydii) and Scedosporium prolificans (formerly S.
Disseminated infections with Scedosporium prolificans have been reported in neutropenic patients including those with underlying blood disorders such as acute leukemia, non-Hodgkin's lymphoma, aplastic anemia and multiple myeloma.
Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans
and Scedosporium apiospermum.
Blood cultures were positive, most commonly revealing Scedosporium prolificans
in more than half of patients.
In vitro activity was determined against 100 isolates of clinically important filamentous fungi and dermatophytes: 62 Aspergillus isolates, 9 Scedosporium prolificans
, 8 Fusarium spp.
The first group corresponded to Scedosporium prolificans (n = 83), and the other 2 comprised isolates previously identified as S.
Use of random amplification of polymorphic DNA (RAPD) and PCR-fingerprinting for genotyping a Scedosporium prolificans (inflatum) outbreak in four leukemic patients.
Airborne outbreak of nosocomial Scedosporium prolificans infection.
Successful control of disseminated Scedosporium prolificans infection with a combination of voriconazole and terbinafine.
Bilateral endogenous Scedosporium prolificans endophthalmitis after lung transplantation.