Members of the genus Pseudallescheria, producing Scedosporium
and eventually Graphium synanamorphs, are frequently found in subcutaneous and systemic infections.
Among the isolates Aspergillus species formed 67% and the remaining 33% was found by Geotrichum, Scedosporium
, and Apophysomyces species equally.
Proceeds of the financing will be used to advance the development of Amplyxs lead candidate APX001 into Phase II clinical trials for the treatment of invasive candidiasis, aspergillosis, and rare molds, including Fusarium, Scedosporium
, and fungi from the Mucorales order.
I, Pigmented hyphae of Scedosporium
apiospermum from a drained abscess at a port site on the chest wall (Papanicolaou, original magnification X40).
The product has received orphan drug designation for four indications: the treatment of invasive candidiasis, invasive aspergillosis, coccidioidomycosis, and rare mold infections caused by Scedosporium
spp, Fusarium spp, and Mucorales fungi.
cepacia complex CF02 Missed by NGS16S Yeast CF06 Presumptive Scedosporium
is a saprobic fungus that naturally occurs in soil, manure, sewage, and water bodies polluted by environmental contaminants.
Phase Two clinical trials in Invasive Aspergillosis and Scedosporium
prolificans infections are planned for the end of 2016.
It's difficultly to diagnose Scedosporium
infection because there is the lack of specific symptoms and signs of fungal infection.
Over 90% of fungal infections are caused by Candida and Aspergillus species; however, there has been an increase in fungal infections caused by rarer species, including Trichosporon, Pseudellescheria, Fusarium, and Scedosporium
8) Infections caused by species of Acremonium, Alternaria, Aspergillus, Candida, Cephalosporium, Curvularia, Fusarium, Pseudallescheria, and Scedosporium
have been reported in dogs (9); whereas, in humans, the most common organisms include Fusarium, Candida, and Aspergillus species.
Dentro de las infecciones micoticas invasivas mas frecuentes se encuentran candida, criptococosis, Scedosporium