hepatocyte growth factor

(redirected from Scatter factor)
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hepatocyte growth factor (HGF)

a potent mitogen and inducer of hepatocyte proliferation, produced in the liver by cells other than hepatic cells and in many other organs by cells of the mesenchyme. It is also multifunctional and regulates cell growth and motility.

hepatocyte growth factor

A cytokine monokine involved in immune and inflammatory responses. It is produced by platelets, fibroblasts, macrophages, endothelial cells, and smooth muscle cells. It stimulates growth of hepatocytes and increases migration and motility of various epithelial and endothelial cells.
See also: factor
References in periodicals archive ?
The c-MET signalling pathway consists of the mesenchymal epithelial transition factor (c-MET) transmembrane tyrosine kinase receptor and its ligand hepatocyte growth factor (HGF) or scatter factor (SF).
Phantom scatter factor and tissue maximum ratios (TMR) were measured and used in the formula to evaluate the calculated PDDs values.
The Competitive Intelligence Report c-MET/HGF Inhibitors as of February 2010 provides a competitor analysis in the development pipeline of novel emerging inhibitors of c-MET receptor tyrosine kinase (RTK) and its ligand hepatocyte growth factor (HGF) or scatter factor (SF) for treatment of solid tumors.