angiotensin II receptor antagonist (redirected from Sartans)

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT₁, AT₂, and others; 1^st generation ARAs included the sartan family of agents, which only block AT₁, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT₁; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.