angiotensin II receptor antagonist

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angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
China ranks first worldwide in output of several bulk APIs including penicillins, vitamins and antipyretic analgesics, and holds a significant share of the featured APIs like statins, prils, sartans in the world.
Capacity expansion in pyridine and its derivatives, commissioning of additional capacity in Niacinamide and multipurpose API facility for Sartans are as per schedule, according to the company official.
Midlands Six East (North West): All Sartans OB, Belper, Chesterfield, Leesbrook, Long Eaton, Meden Vale, Tupton, Uttoxeter, Keyworth, Boots Athletic.
and anti-lipemic agents was increased greatly, especially the best-sellers of statins, prils and sartans, which had been the major export raw material medicines against the cardiovascular disease in the international market.
are the key suppliers of featured APIs in China, of which the former specializes in antineoplastic and cardiovascular products, and the latter, which obtains three certificates from EDQM in 2013, is a major global supplier of prils and sartans APIs.
Germany: The three levels of reference pricing; off-patent and patent-protected drugs; the introduction of more aggressive reference prices; statins, sartans, and PPIs; incentives to undercut reference prices; 2007 price adjustments; market impact and pricing trends; cumulative savings from reference pricing; penetration of reference-priced drugs into the German pharmaceutical market.
Most countries that practice reference pricing limit it to drugs that are off patent, but Germany has recently extended this measure to several drug classes that include patent-protected medicines: proton pump inhibitors, sartans, triptans, antianemic agents, fluoroquinolones, heparins, macrolides, serotonin (5-HT3) receptor antagonists, triazole antimycotics, and-most notably-statins.
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