angiotensin II receptor antagonist

(redirected from Sartan)

angiotensin II receptor antagonist

Any of a family of agents (e.g., losartan and valsartan) that block the binding of angiotensin II (A-II) to their cognate cell receptors—AT1, AT2 and others. First-generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains to block the binding of A-II to AT1.

ARAs are an alternative to ACEI therapy in patients with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference of which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.

angiotensin II receptor antagonist

Pharmacology Any of a family of agents-eg losartan and valsartan, which block the binding of angiotensin II–A-II to its cognate cell membrane receptors–AT1, AT2, and others; 1st generation ARAs included the sartan family of agents, which only block AT1, interacting with the amino acids in the transmembrane domains, blocking the binding of A-II to AT1; an alternative to ACEI therapy for Pts with CHF; unlike ACEIs, ARAs do not interfere with bradykinin and prostaglandin metabolism, interference which has been linked to some of the adverse effects of ACEI therapy, particularly to cough and angioedema.
References in periodicals archive ?
Regional police in Mariupol, a port city on the Sea of Azov, said at least one man and a young woman were killed when rebels shelled the town of Sartan, about 20 km (12 miles) away on Sunday.
La practica de la Division de Signos Distintivos de la sic demuestra que particulas como "astina" han sido usadas en numerosas marcas para registros solicitados bajo la nueva legislacion andina; otras marcas, como relazepam, caen en el mismo ejemplo; pero los ejemplos mas impactantes los constituyen marcas como NIDAZOL y SARTAN, que se componen exclusivamente de la particula que determina la familia farmacologica de la DCI.
There are more than 20 compound preparations of sartan drugs in global market.
At least 227 Afghan soldiers and police have been killed in the four months of Hamal, Sawr, Jawza, and Sartan, the first quarter of the Afghan year (April 20 to July 21, 2012).
Further, during the Sartan Ice Age there was a forest refugium in the middle reach of the Anadyr (Kozhevnikov and Zheleznov-Chokotskij 1995) where a moose population most closely related to Alaskan moose might have existed.
ARBs can be identified by their name ending sartan.
The demand is overwhelming for the two clinical pharmacists on duty, Al Prazolam and Val Sartan.
The author suggests a connection between palatalization and labialization, but senter - senter 'splinter', wagessa - wagessa 'traditional medical practitioner' as well as Arabic loanwords, such as sarian - sartan 'crab', saytan - saytan 'Satan' seem to indicate that there is no connection between palatalization and labialization.
PHOTO : this steel engraving by John Sartan, circa 1850.
Lower prices were also implemented on Adrovance([R]), for which the price was reduced by 25% in May 2010, and the sartan drug category, of which Nisis([R]) and Nisisco([R]), with an 11% price reduction effective as of September 2010.
Lower prices were also imposed on Adrovance([R]), for which the price was reduced by 25% in May 2010, and the sartan drug category, of which Nisis([R]) and Nisisco([R]), with price reductions effective as of September 2010.
Available since August 2007, Exforge([R])combines in a single tablet the power of two of the most widely-prescribed and widely studied antihypertensive drugs: valsartan, a sartan issued from Novartis research, and amlodipine, a calcium inhibitor.