Salvarsan


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Related to Salvarsan: Salvarsan 606

Sal·var·san

(sal'var-san),
Historic proprietary name for arsphenamine.
[L. salvare, to preserve, + sanitas, health]

salvarsan

(săl′vər-săn′)
n.
The drug arsphenamine.
The 606th arsenical compound synthesised by Paul Ehrlich
Pros It was the first effective therapy for syphilis
Cons Toxicity, difficult to administer, long-term therapy required. It was superseded by penicillin in 1943

Salvarsan

Medical history An antisyphilitic arsenical compound synthesized by Paul Ehrlich. See Magic bullet.
References in periodicals archive ?
In yet another interesting perspective, Rosen notes how the exciting promise of advances in pharmaceutical chemistry that occurred right up until the introduction of an improved version of Salvarsan (called Neosalvarsan) in 1912 was short-circuited by the global conflagration that impeded such research beginning in August 1914.
Aunque siempre tuvo a su disposicion laboratorios y fondos economicos, esta relacion fue determinante en la realizacion de los 606 ensayos efectuados en ratones, conejillos de indias y conejos, que culminaron con la comprobacion de que el derivado del arsenico por el llamado Salvarsan (que salva por medio del arsenico) era eficaz contra la temible espiroqueta causante de la sifilis o Treponema pallidum (5), descubierta tiempo atras por Schaudinn y Hoffmann en Berlin.
The scientist Paul Ehrlich, who was awarded the Nobel Prize for medicine in 1908, tested various forms and various doses of his "Magic Bullet" Salvarsan, on prostitutes handed over to him by the police.
Modern chemotherapy got its start in the early part of this century, when the German bacteriologist Paul Ehrlich and his research team discovered that a dye called trypan red could kill trypanosomes--parasites that cause sleeping sickness--and that a chemical he named salvarsan destroyed the spirochete microbe that leads to syphilis.
Additionally, from 1912 onwards, modest amounts of salvarsan (an arsenic-based cure for syphilis) were manufactured.
His shinning success was the discovery of salvarsan in 1910, an arsenical compound effective against the spirochaete causing syphilis.
En poco tiempo se podra cerrar un circuito infeccioso que comenzo hacia 1910, cuando Paul Ehrlich, medico aleman, probo por primera vez en seres humanos el salvarsan para tratar la sifilis.
En 1910, Julian Arce escribiria que lo ideal seria descubrir un 'agente terapeutico especifico', como por ejemplo la quinina para la malaria, y el preconizo el uso del salvarsan para la bartonelosis (22), que fue empleado hasta la llegada de los antibioticos, dado que ya en 1944 se publico el primer caso de bartonelosis tratado exitosamente con penicilina (23,24).
Part II, Chemical, technological and histological concepts of aniline colors>> (4), as well as his work on chemical dyes developed in the Medical Clinic of Berlin, as Professor Frerichs'2 assistant, took him later to discover salvarsan, the first known curative medicine for syphilis.
She would have been about nine years old when the first antibiotic, salvarsan, was developed by the German bio-chemist Paul Erlich, and now we have thousands of anti-biotics.
11) As part of the famous German preparation, Salvarsan, it was used in the past for sexually transmitted disease.
Cuando ya habia probado con 605 compuestos de arsenico, encontro el salvarsan o arsfenamida o simplemente, el 606, compuesto que resulto eficaz contra la sifilis y represento un gran avance en la lucha contra las infecciones, ya que se descubrio el primer compuesto quimico que atacaba el agente causal de la enfermedad.