margin of safety

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margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
According to Eqs (20)-(23), the means and variances of revised safety margins of normal sections as particular members of the considered precast concrete beams may be expressed as follows:
k] may be treated as statistically independent variables of random safety margins.
As Table 1 shows, half the safety margins in the severe bend condition were 0 or less (the median safety margin was 0).
Even with modern biphasic ICDs, inadequate safety margin (>10 J) has been reported in up to 6.
The variations that many foundries have taken for granted not only mean unnecessary scrap but also that a high safety margin must be used in gating and risering systems, resulting in low yield.
In addition, the reliability of the reconstructed data is calculated to supply the surgeon with accurate information concerning nerve tract locations, paths, and intersections and to construct safety margins around the nerve fiber tracts.
The alternate site is Kahilipali Point, farther south around the island, which according to the study offers the same safety margins but with a complicating factor.
Safety margins observed in the Phase 1b clinical trial at Brigham and Womens are consistent with the Company's extensive pre-clinical data demonstrating that CGX-1160 is a broad spectrum non-opioid analgesic with a wide safety margin.
Technology changes and reliability of this equipment require it to be cycled out and replaced no later than five years from initial purchase to ensure safety margins and no fault operations.
But the CAA said that did not mean safety had been put at risk, as there were safety margins even within the overload system.
An improved NDE technology that lowers the threshold of damage detection will lead to lower costs by reducing the number of periodic inspection intervals and extending the service life of operational components that are retired early due to conservative safety margins.