margin of safety

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margin

 [mahr´jin]
an edge or border.
gingival margin gum margin.
gum margin the border of the gingiva surrounding, but unattached to, the substance of the teeth.
margin of safety a calculation that takes the highest animal no observed adverse effect level and estimates a maximum safe level of exposure for humans. It is now generally superseded by the reference dose.

mar·gin of safe·ty

the range between the minimal therapeutic dose and the minimal toxic dose of a drug.

margin of safety

an index of a drug's effectiveness and safety. It is calculated as the amount of drug that is lethal to 1% of animals (LD1) divided by the amount of drug that causes a beneficial effect in 99% of the animals (ED99). See also dose-response relationship.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The area between the minimal therapeutic dose and the minimal toxic dose of a drug.
Synonym(s): safety margin.

mar·gin of safe·ty

(mahr'jin sāf'tē)
The gap (i.e., range) between the minimal therapeutic dose of a drug and its minimal toxic dose.
References in periodicals archive ?
Therefore, three stochastically dependent safety margins should be considered as follows
By using the smallest lane width, we obtained the most conservative safety margins.
Considering the uncertainties surrounding earthquake safety, it would be ill-advised to rely only on estimated safety margins.
Efficacy and temporal stability of reduced safety margins for ventricular defibrillation: primary results from the Low Energy Safety Study (LESS).
The resulting safety margins are the most restrictive in the world: On the basis of the same available data, most other scientific agencies in the United States and around the world have established much higher minimum exposure levels.
At this stage, a safety margin of 10 percent can be suggested, which means that a placement offset of [+ or -] 40 percent off-pad can be recommended.
As a first step, Toyota and Volkswagen are seeking to jointly develop environmentally friendly exhaust components and brake systems with improved safety margins for new compact cars to be produced in Europe, the Nihon Keizai Shimbun said.
The effect is much less variation in properties, which manifests itself in less scrap due to metallurgical reasons, and a possibility to reduce safety margins in gating and risering.
But safety margins based on outdoor use may not protect greenhouse workers, asserts J.
Provision of a system of artificial snow in the ski resort and the elements necessary for its operation, which increases with adequate safety margins, the presence of snow in a wide area of ?
They are BETTER than younger folk when it comes to safety margins and dealing with hazards.