Sabin-Feldman dye test


Also found in: Dictionary, Thesaurus, Encyclopedia.

Sa·bin-Feld·man dye test

(sā'bĭn feld'măn),
a method for the detection of antitoxoplasma antibody in serum, based on the finding that Toxoplasma gondii cells (from peritoneal exudate in mice) are fairly well stained with alkaline methylene blue, whereas organisms in a serum that contains specific antibody have no affinity for the dye; furthermore, normal toxoplasma cells become rounded, and the nucleus and cytoplasm deeply stained, when treated with methylene blue; conversely, when dye is mixed with organisms and antibody, the cells retain their crescent shape and only the shrunken nuclear endosome is stained.

Sabin-Feldman dye test

[sā′bin feld′mən]
Etymology: Albert B. Sabin, American virologist, 1906-1993; H.A. Feldman, American epidemiologist, b. 1914; AS, deag + L, testum, crucible
a serological test for the diagnosis of toxoplasmosis that depends on the presence of specific antibodies that block the uptake of methylene blue dye by the cytoplasm of the Toxoplasma organisms.

Feldman,

Harry Alfred, U.S. epidemiologist, 1914–.
Sabin-Feldman dye test - see under Sabin
Sabin-Feldman syndrome - see under Sabin

Sabin,

Albert Bruce, U.S. epidemiologist, 1906-1993.
Sabin-Feldman dye test - a method for the detection of antitoxoplasma antibody in serum.
Sabin-Feldman syndrome - chorioretinitis and cerebral calcifications.
Sabin vaccine - an orally administered vaccine containing live, attenuated strains of poliovirus.