SV40


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SV40

SV40

(ĕs′vē-fôr′tē)
n.
A polyomavirus found in humans and other mammals that causes tumors in certain species, such as hamsters and rats, and various diseases in immunocompromised monkeys. It has been widely researched as a model of viral replication and gene expression and a possible cause of certain cancers in humans.

SV40

abbreviation for simian virus 40.
References in periodicals archive ?
The authors say that approximately 98 million Americans thus were at high risk for exposure to the SV40 virus.
Se habia revelado un misterio: SV40 transformaba las celulas inactivando la funcion de la proteina p53.
2 in Basic Virology [12], illustrating the replication cycle of the closely related SV40 in a permissive cell, shows no viral integration but provides no references to associated experimental evidence.
Human mammary epithelial cells can be induced to undergo a transformation to a neoplastic phenotype, through the viral mediated introduction of three genes SV40 ER, hTERT, and an oncogenic form of hRAS, hRASv 12.
BL-4040 is a genetically-engineered version of the major capsid protein VP1, derived from the outer protein shell of the virus SV40, therefore it does not contain any viral material.
In this work, a sebaceous gland cell line, SEB-1, which was produced by SV40 immortalisation of human sebocytes, was incubated with 13-cis-RA, 9-cis-RA and ATRA.
Figure 4 illustrates the icosahedral shape of the SV40 virus and shows an electron micrograph of these icosahedral viral particles.
HYPERACETYLATED HISTONE H4 ON THE SV40 GENOME DURING THE
Early studies reported the detection of polyomavirus SV40 DNA sequences in NHL from HIV-infected and non-HIV-infected patients, but the small size of the study populations, the lack of screening for other tumor viruses, and the limited confirmation of the detected viral sequences made it difficult to assess wether SV40 was associated with NHL.
SV40 was first transmitted to humans between 1955 and 1963 in contaminated batches of polio vaccine.