AURKA

(redirected from STK15)

AURKA

A gene on chromosome 20q13 that encodes Aurora kinase A, which is involved in regulating many early mitotic events such as entry into mitosis. Aurora A levels rise during the G2 phase and peak early in mitosis. It is highly expressed in the testes, as well as in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
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a) Common Sequence ID Official gene gene name symbol BAG1 NM_004323 BAG1 Bcl2 NM_000633 BCL2 CCNB1 NM_031966 CCNB1 CD68 NM_001251 CD68 CEGP1 NM_020974 SCUBE2 CTSL2 NM_001333 CTSL2 EstR1 NM_000125 ESR1 GRB7 NM_005310 GRB7 GSTM1 NM_000561 GSTM1 HER2 NM_004448 ERBB2 Ki-67 NM_002417 MKI67 MYBL2 NM_002466 MYBL2 PR NM_000926 PGR STK15 NM_003600 AURKA STMY3 NM_005940 MMP11 SURV NM_001168 BIRC5 -Actin NM_001101 ACTB GAPDH NM_002046 GAPDH GUS NM_000181 GUSB RPLPO NM_001002 RPLP0 TFRC NM_003234 TFRC (a) Genes annotated with NCBI LocusLink sequence identification numbers and official gene symbols of the HUGO Gene Nomenclature Committee (http://www.
While the majority of these 16 genes were found to be estrogen receptor-related (ESR1, PGR, BCL2, SCUBE2) and proliferation-related (Ki67, STK15, Survivin, CCNB1, MYBL2), some genes did not belong to these 2 categories (HER2, GRB7, MMP11, CTSL2, GSTM1, CD68, BACG1).
Researchers from Arizona and Telik are presenting data on the use of TRAP to identify potential inhibitors of a newly discovered genomics-based cancer target, STK15, which may play a role in the oncogenic transformation of pancreatic cancer cells.