SPINK1


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.

SPINK1

A gene on chromosome 5q32 that encodes a trypsin inhibitor secreted from pancreatic acinar cells into pancreatic juice. SPINK1 is thought to prevent trypsin-catalysed premature activation of zymogens within the pancreas and the pancreatic duct.

Molecular pathology
SPINK1 mutations are associated with hereditary pancreatitis and tropical calcific pancreatitis.
References in periodicals archive ?
Interestingly, SPINK1 production is not associated with an adverse prognosis in all tumors.
It is likely that humanized SPINK1 antibodies to be used for treatment of human tumors are under development.
Role of the tumor-associated trypsin inhibitor SPINK1 in cancer development.
The analysis approach used to identify SPINK1 has been named Meta-COPA and will soon become a standard feature within the Oncomine platform.
We evaluated the presence of 125G/C, 1001>11>CT, 1540A>G (Met470Val), 2694T>G, and 4521G>A variants in CFTR and the 272C>T polymorphism in SPINK1 by direct sequencing.
PRSS1, SPINK1, AND CFTR GENE MUTATIONS IN HTG PATIENTS WITH AND WITHOUT HLP