spherocytosis, hereditary, type 3

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spherocytosis, hereditary, type 3

An autosomal recessive haematologic disorder (OMIM:270970) characterised by numerous abnormally shaped, generally spheroid erythrocytes accompanied by severe haemolytic anaemia.

Molecular pathology
Caused by defects of SPTA1, which encodes an alpha erythrocyte spectrin and major scaffold protein linking the plasma membrane to the actin cytoskeleton.
References in periodicals archive ?
In a very compact footprint and with an SPH3 frame to prevent any spill, we also have the polyethylene hardhat canopy to prevent any rust or corrosion and we have a vertical mast to improve the footprint and improve the safety, by minimising the risk of any mask fall down during the installation.