specific pathogen free

(redirected from SPF status)

specific pathogen free

a term applied to animals reared for experimentation or to commence new herds or flocks of disease-free animals; abbreviated SPF. Animals usually obtained as for axenic animals but are then placed into a nonsterile environment in which they become infected with a range of microorganisms, many colonizing as so-called normal flora. Certain defined specific pathogenic microorganisms are not present in the environment so that SPF animals can be stated to be free of infection or previous infection with the specified microorganism. See also gnotobiotic animal.
References in periodicals archive ?
The APiX Simian Pathogen Array coupled with the APiX View Detection Kit is ideal for colony managers to routinely monitor the SPF status of their animals, to maintain high standards of animal and caretaker health and to provide confidence in the integrity of studies using these animals.