KLK6(redirected from SP59)
Also found in: Acronyms.
KLK6A gene on chromosome 19q13.3 that encodes a serine protease that catalyses amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins (such as fibronectin, laminin, vitronectin and collagen). It may be involved in regulating axon outgrowth following spinal cord injury. KLK6 may play a role in invasion and metastasis.
KLK6 degrades alpha-synuclein, preventing its polymerisation, suggesting a role in the pathogenesis of Parkinson disease and other synucleinopathies.