SOX4

SOX4

A gene on chromosome 6p22.3 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX4 may act as a transcription regulator after forming a complex with other proteins (e.g., syndecan-binding protein) as well as play a role in apoptosis and tumourigenesis; it may mediate the downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development.
References in periodicals archive ?
Upregulated expression of SOX4 is associated with tumor growth and metastasis in nasopharyngeal carcinoma.
Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3.
Estrogen induces androgen-repressed SOX4 expression to promote progression of prostate cancer cells.
La metastasis de cancer de seno y migracion son inhibidas por miR-335 que tiene como blanco el factor de transcripcion SOX4, que se sabe regula el desarrollo celular y la migracion (Tavazoie et al.
miRNAs Blanco asociado Funcion del miRNA en metastasis de tumor miR-10b HOXD10 Promotor miR-21 PTEN, PDCD4, TPM1, Maspin Promotor miR-373 CD44, LATS2 Promotor miR-520c CD44 Promotor miR-155 RhoA Promotor Let-7 Ras, HMGA2 Represor miR-335 SOX4, TNC Represor miR-126 Crk, IRS-1 Represor miR-146a ROCK1 Represor miR-101 EZH2 Represor Familia miR-200 ZEB1, ZEB2 Represor
The lab also found how SOX4, SOX11, and SOX5 - sections of DNA called transcription factors - control the expression of genes and operate cooperatively to shape this network in the developing embryo.
RSP03, SOX4 ve FONG genleri KMY ile iliskili bulunmustur (52,53).
5] Genes: PDCD4, programmed cell death 4 (neoplastic transformation inhibitor); TPM1, tropomyosin 1 (alpha); PTEN, phosphatase and tensin homolog; TIMP3, TIMP metallopeptidase inhibitor 3; SOCS1, suppressor of cytokine signaling 1; ZBTB10, zinc finger and BTB domain containing 10; RHOC, ras homolog gene family, member C; CD44, CD44 molecule (Indian blood group);BRMS1, breast cancer metastasis suppressor 1; SOX4, SRY (sex determining region Y)-box 4; TNC, tenascin C; CDC42, cell division cycle 42 (GTP binding protein, 25kDa); CXCR4, chemokine (C-X-C motif) receptor 4; CYP19A1, cytochrome P450, family 19, subfamily A, polypeptide 1.
miR-335 has been reported to target a set of genes which are required for tumor metastasis such as SOX4 and TNC (50).
A recent large-scale microarray analysis of 15 cases of ACC found the transcription factor-encoding gene SOX4 was significantly overexpressed in ACC relative to normal salivary gland tissue.