SOX2


Also found in: Wikipedia.

SOX2

A gene on chromosome 3q26.3-q27 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX2 is required for stem-cell maintenance in the CNS and regulates gene expression in the stomach.

Molecular pathology
SOX2 mutations are associated with optic nerve hypoplasia and syndromic microphthalmia.
References in periodicals archive ?
The research team targeted two genes that are only expressed in stem cells and known to be integral to pluripotency: Sox2 and Oct4.
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
2012) Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells.
SOX2 promotes the epithelial to mesenchymal transition of esophageal squamous cells by modulating slug expression through the activation of STAT3/HIF-a signaling.
The results showed that 500 ng/mL ascorbic acid treatment in the first 24 h of embryo development significantly increased the expression levels of Pou5f1, Sox2, and Klf in blastocysts (Figure 3).
As shown in Figure 3, Creb314, Tpd52, Pitx3, Paqr4, and Sox2 were hypomethylated at promoter CpG sites by neonatal high-dose [E.
SOX1, SOX2 and NES expression was also reduced dramatically with differentiation, showing very small positive populations at 8 weeks (2%, 3% and 2%, respectively) (Fig.
Furthermore, we showed that CA promoted proteasomal degradation of several substrate proteins, including Cyclin Bl, retinoblastoma (RB), SOX2, and glial fibrillary acid protein (GFAP), whereas MYC levels were not modified.
pylori] inhibits the expression of SOX2 in gastric epithelial cells, hence activating transcription factor CDX2 as a counterpart to MUC5AC gene inhibition andMUC2 gene induction," elaborated Dr.
The research findings described in this media release can be found in the Cell Journal, under the title, "Long-Lived Binding of Sox2 to DNA Predicts Cell Fate in the Four-Cell Mouse Embryo" by Melanie D.
Sheep gene mapping: Assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.