SOX18

SOX18

A gene on chromosome 20q13.33 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX18 may act as a transcription regulator after forming a complex with other proteins; it plays a role in the development of hair, blood vessels and lymphatic vessels.

Molecular pathology
SOX18 mutations are associated autosomal recessive and dominant forms of hypotrichosis-lymphedoema-telangiectasia.
References in periodicals archive ?
Yapilan calismalarda lenfatik sistemin gelisiminde VEGFR3 (vaskuler endotelyal buyume faktor reseptor 3), PROX1 (prospero-iliskili homeobox-transkripsiyonel faktor), FOXC2 (forkhead transkripsiyonel faktor) ve SOX18 genlerinin rol oynadigi saptanmistir.
The second class contains genes that control cell differentiation during the development of a number of tissues (SOX11, SOX18, HEY1, CART1, PRX2, SMAD7, ID1).