SOX17

SOX17

A gene on chromosome 8q11.23 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX17 may act as a transcription regulator after forming a complex with other proteins.
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The team discovered that the progenitors could be converted into blood vessel cells or into red blood cells, depending on the level of a gene transcription factor called SOX17.
As progenitor cells were differentiating into blood vessel cells, levels of the transcription factor SOX17 became elevated.
This list includes ADHFE1, ALX4, CNRIP1, EID3, ELMO1, ESR1, FBN1, HLTF, LAMM, NEUROG1, NGFR, RARB, RXRG, RYR2, SDC2, SEPT9, SFRP2, SOCS3, SOX17, THBD, TMEFF2, UCHL1, and VIM genes.
Less studied putative CRC biomarkers, such as CNRIP1 [22], ADHFE1 [23], UCHL1, ELM01 [24], LAMA1 [25], and SOX17 [26], were also examined.
DE markers FOXA2, SOX17 and CXCR4 and also pluripotency marker OCT4 were evaluated using qRT-PCR, as well as FOXA2 by the immunocytochemistry.
Mutations in SOX17, which regulate [beta]-catenin, are observed exclusively in this subgroup.
SOX2 is expressed in the nuclei of embryonal carcinoma but is not expressed in those of seminoma, (26-29) whereas SOX17 shows nuclear reactivity in seminoma but not in embryonal carcinoma.
8 cytoplasmic, calcineurin-dependent 2 599590 SOX17 SRY (sex determining region Y)-box 1.
Researchers at the Gurdon Institute found that a gene known as SOX17 is critical for directing human stem cells to become PGCs (a stage known as 'specification').
Global analysis of CpG island hypermethylation and gene expression in colorectal cancer cell lines has revealed that SOX17 gene silencing is associated with DNAhypermethylation (17), and SOX17 plays a tumor suppressor role through suppression of Wnt signaling (18).
SOX17 gene silencing is associated with DNA hypermethylation of a C-phosphate-G (CpG) island located in the promoter region (29).