SOX11

SOX11

A gene on chromosome 2p25 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX11 may act as a transcription regulator after forming a complex with other proteins; it may play a role in development of the nervous system and in tumourigenesis.
References in periodicals archive ?
Importantly, neither cyclin D2 nor cyclin D3 is specific for MCL, (17) but nuclear expression of SOX11 is a specific marker associated with MCL, according to Chen et al (18) (Figure 1, B and C).
Assessment of SOX11 expression in routine lymphoma tissue sections: characterization of new monoclonal antibodies for diagnosis of mantle cell lymphoma.
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtypes [published correction appears in Haematologica 2010; 95(9):1620].
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
Another example of progress in immunohistochemistry is the identification of SOX11 as a marker of mantle cell lymphoma (MCL), including the occasional cases that are negative for cyclin D1.
The lab also found how SOX4, SOX11, and SOX5 - sections of DNA called transcription factors - control the expression of genes and operate cooperatively to shape this network in the developing embryo.
The authors also show that SOX4 and SOX11 are imperative for the layering of the neocortex, an essential change that led to increased complexity of the brain organization in mammals, including humans.
In such cases, studies have shown that mantle cell lymphoma will express the SOX11 protein.
SOX11 is a member of the SOX family and encodes a transcription factor.
Cyclin D1negative blastoid mantle cell lymphoma identified by SOX11 expression.
SOX11 performed on the spleen resection was negative (performed by the panel of reviewers for the European Association of Hematopathology Workshop, Uppsala, Sweden).
10,11) Mantle cell lymphomas, including those negative for cyclin D1, are positive for SOX11 in 78% to 93% of cases, whereas SOX11 is uniformly negative in chronic lymphocytic leukemia/small lymphocytic lymphoma.