SOX11

SOX11

A gene on chromosome 2p25 that encodes a member of the SOX (SRY-related HMG-box) family of transcription factors, which regulate embryonic development and determine cell fate. SOX11 may act as a transcription regulator after forming a complex with other proteins; it may play a role in development of the nervous system and in tumourigenesis.
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SOX11 performed on the spleen resection was negative (performed by the panel of reviewers for the European Association of Hematopathology Workshop, Uppsala, Sweden).
10,11) Mantle cell lymphomas, including those negative for cyclin D1, are positive for SOX11 in 78% to 93% of cases, whereas SOX11 is uniformly negative in chronic lymphocytic leukemia/small lymphocytic lymphoma.
13) SOX11 has been found to be variably expressed in the blastoid variants of mantle cell lymphoma.
16) Importantly, whereas typical mantle cell lymphoma cells usually express SOX11 protein, cells of indolent mantle cell lymphomas may lack expression of SOX11, suggesting that this marker may be useful in predicting clinical behavior.
These cases of indolent mantle cell lymphoma frequently lack CD5 and SOX11 expression, which may or may not prove to be useful diagnostic predictors of clinical behavior.
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX11 expression.
The lab also found how SOX4, SOX11, and SOX5 - sections of DNA called transcription factors - control the expression of genes and operate cooperatively to shape this network in the developing embryo.
The authors also show that SOX4 and SOX11 are imperative for the layering of the neocortex, an essential change that led to increased complexity of the brain organization in mammals, including humans.