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J.F., 20th-century U.S. pediatrician. See: Sotos syndrome.


A gene on chromosome 5q35 that encodes a protein that  enhances androgen receptor transactivation, especially in the presence of other androgen receptor-associated coregulators. NSD1 acts as a nucleus-localised, basic transcriptional factor and as a bifunctional transcriptional regulator.

Molecular pathology
NSD1 mutations cause Sotos syndrome and Weaver syndrome, as well as a form of childhood acute myeloid leukaemia with a cryptic translocation, with breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, trithorax domain protein 1 on chromosome 5 and nucleoporin 98-kD on chromosome 11.
References in periodicals archive ?
Much of the appeal of the new SOTO worktool platform lies in its ability to minimize visual clutter with clean lines and quiet aesthetic.
Worksurfaces are shrinking, thanks to the popularity of flat-panel monitors and the trend toward freestanding environments," says Jeff Charon, SOTO category manager.
When questioned about the accuracy of the study, (the supervisor) indicated that the Sotos were failed because Adoptions did not think it was in the best interest of the child for the Sotos to obtain custody, rather than because they were unfit.
that) gives the distinct impression of being written by a person with an intense dislike for the Sotos and with the goal of justifying rejecting their request to adopt.