SOD3

SOD3

A gene on chromosome 4p15.3-p15.1 that encodes an extracellular superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress.
References in periodicals archive ?
Mice null for cytosolic SOD1 and extracellular SOD3 are viable (Matzuk et al.
They found that the presence of single nucleotide polymorphisms, or SNPs, variations in DNA sequences, in SOD3 that were linked to lung function in mice.
For further analysis, the researchers went on to assess SOD3 mutations in children ages 9 to 11 by testing for SNPs linked to lung function.
One of these SNPs likely alters the expression levels of SOD3.
Previously, genetic variants in SOD3 have been associated with loss of lung function in COPD, which is mainly caused by cigarette smoking.
1990), Cu/Zn SOD mRNA levels remain constant, but SOD3 (MnSOD) mRNA levels increased throughout postgermination scutellar development.
Pattern 9 included 806 genes that were induced at 24 hr, including CCNDBP1 (a negative regulator of E2F1), the stress-response genes GSTM3 and SOD3, and p53-dependent genes (TP53BP1 and TP53T[G.
SOD1 (copper-zinc SOD) found in cytosol, SOD2 (manganese SOD) found in mitochondria and SOD3 (extracellular SOD) found extracellularly, is known to catalyze dismutation of superoxide radicals into [H.