SOD3

SOD3

A gene on chromosome 4p15.3-p15.1 that encodes an extracellular superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen. SOD3 is thought to protect the brain, lungs and other tissues from oxidative stress.
References in periodicals archive ?
The glycocalyx also consists of a wide range of enzymes (eNOS, ACE, SOD3, etc.
Serum protein S100A9, SOD3, and MMP9 as new diagnostic biomarkers for pulmonary tuberculosis by iTRAQ- coupled two-dimensional LC-MS/MS.
We previously reported that a treatment with TPA activated HAT including p300 and GCN5, which contribute to the TPA-elicited expression of SOD3 in human leukemic THP-1 cells [29], suggesting that TPA-elicited Slug expression might be associated with the activation of HAT.
Three superoxide dismutases enzymes have been identified and characterized in mammals: cooper/zinc superoxide dismutase (Cu/ZnSOD encoded by SOD1 gene) manganese superoxide dismutase (MnSOD encoded by SOD2 gene) and the extracellular superoxide dismutase (ECSOD encoded by SOD3 gene) (Fridovich 1995; Miao and Clair 2009).
SOD3 has primary control over the inactivation of nitric oxide and plays an important role in controlling oxidative stress and intercellular signaling (BoiTelli, 2014).
Sadece keratokonuslu stroma keratositlerinde IL-1'in (interlokin) korneal SOD3 (superoksit dismutaz) sentezini yavaslatmaktadir.
Mice null for cytosolic SOD1 and extracellular SOD3 are viable (Matzuk et al.
They found that the presence of single nucleotide polymorphisms, or SNPs, variations in DNA sequences, in SOD3 that were linked to lung function in mice.
1990), Cu/Zn SOD mRNA levels remain constant, but SOD3 (MnSOD) mRNA levels increased throughout postgermination scutellar development.
Table 1: Redox Panel Nutrient Gene Variant Genotype Gene Codes for: Cofactor SOD2 Vall6Ala (OT) No variant Superoxide Manganese (MnSOD) impact dismutase (mitochondrial) MnSOD SOD3 760 OG cc Superoxide Copper dismutase and Zinc (extracellular) CuZnSOD GPX1 GPX1 Prol98Leu CT Glutathione Selenium (C>T) peroxidase (GPx)
SOD3 is present in plasma, tissues, and extracellular fluids such as synovial fluid and lymph.
The cytosolic and extracellular SOD (SOD1 and SOD3, respectively) contain copper and zinc, while the mitochondrial (SOD2) contains manganese (Zelko et al.