SOD2

SOD2

A gene on chromosome 6q25.3 that encodes a mitochondrial  superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen.

Molecular pathology
SOD2 mutations are associated with idiopathic cardiomyopathy, premature ageing, sporadic motor neurone disease, and cancer.
References in periodicals archive ?
Gene Sequence GAPDH Forward 5'-ATGGGAAGCTGGTCATCAAC-3' Reverse 5'-GTGGTTCACACCCATCACAA-3' SOD1 Forward 5'-CAGGACCTCAnTTAATCCTCAC-3' Reverse 5'-CCCAGCTCTCCAACATGC-3' SOD2 Forward 5'-CACAAGCACAGCCTCCCAG-3' Reverse 5'-CGCGTTAATGTGTGGCTCC-3' GPx-1 Forward 5'-ACAGTCCACCGTGTATGCCTTC-3' Reverse 5'-CTClTCATTCTTGCCATTCTCCTG-3' Nrf2 Forward 5'-TTCCTCTGCTGCCATTAGTCAGTC-3' Reverse 5'-GCTCTTCCATTTCCGAGTCACTG-3' HO-1 Forward 5'-CTGGAAGAGGAGATAGAGCGAA-3' Reverse 5'-TCTTAGCCTCTTCTGTCACCCT-3'
Some genetic polymorphisms in HMOX1, NOS3, SOD2, CYBA, and APOE have been shown to modify As-induced cardiovascular outcomes (Hsieh et al.
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation.
SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy.
Oxidative stress was linked with upregulation of SOD2 in podocytes.
Specifically, the candidate genes are as follows: COMT (neurotransmission), SOD2 (oxidative stress elimination) and ESR1 and ESR2 (oestrogen action facilitators).
Association of SOD2, a mitochondrial antioxidant enzyme, with gray matter volume shrinkage in alcoholics.
They found patients with two versions of the SOD2 fared worse when taking the chemotherapy drug cyclophosphamide than other patients.
The findings, by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and colleagues, show how a genetic variant, located in the SOD2 gene, may affect how a person responds to the chemotherapy drug cyclophosphamide.
gattii SOD2 reveals distinct roles of the two superoxide dismutases in fungal biology and virulence.
The SOD2 gene encodes an intramitochondrial free radical scavenging enzyme, the first line of defense against superoxide produced by oxidative phosphorylation.
By removing an acetyl group of the mitochondrial antioxidant enzyme SOD2, SIRT3 reduces free radical oxidation.