SOD2

SOD2

A gene on chromosome 6q25.3 that encodes a mitochondrial  superoxide dismutase which binds superoxide byproducts of oxidative phosphorylation, converting them to hydrogen peroxide and diatomic oxygen.

Molecular pathology
SOD2 mutations are associated with idiopathic cardiomyopathy, premature ageing, sporadic motor neurone disease, and cancer.
References in periodicals archive ?
Due to its localization within the mitochondria, manganese SOD (Mn-SOD, coded by the SOD2 gene) is the most effective member of the SOD family of enzymes in protecting the mitochondria from oxidative stress induced by enzymatically scavenging superoxide anions (4, 5).
Earlier, there were many studies related to polymorphism screening by applying computational approach to predict the functional missense mutations associated with gene like ubiquitin-specific protease 9, Y chromosome, USP9Y (41); Deleted in Azoospermia Like, DAZL (42); Superoxide Dismutase 2, SOD2 (43); Phosphatase and tensin homolog, PTEN (44).
The accession numbers (in parentheses) and the Na+/H+ antiporter sources are as follows: AgNHX1 (AB038492), Atriplex gmelini; AtNHX1 (AF510074), AtSOS1 (AF256224), and AtSOS1 (AY062746), Arabidopsis thaliana; NHE2 (AAD41635) and NHE5 (AAC98696), Homo sapiens; OsNHA1 (AY328087), Oryza sativa; TaSOS1 (AY326952), Triticum aestivum; PpSOS1 (AJ564258), Physcomitrella patens; PeNhaD1 (AJ561195), Populus euphratica; NhaP (BAA31695), Pseudomonas aeruginosa; NHA1 (NP-013239), Saccharomyces cerevisiae; SOD2 (CAA77796), Schizosaccharomyces pombe; NhaA (P13738), Escherichia coli; and PeSOS1 (DQ517530), Populus euphratica
Superoxide dismutase gene (SOD1, SOD2, and SOD3) polymorphisms and antituberculosis drug-induced hepatitis.
ATP5O, GSTM5, ASRGL1, and SOD2 levels were significantly different in all treated groups compared with the control.
SOD2 is encoded by the nuclear SOD2 gene located on the human chromosome 6q25 and the Ala16Val polymorphism has been identified in exon 2 of the human SOD2 gene.
Table 1: Redox Panel Nutrient Gene Variant Genotype Gene Codes for: Cofactor SOD2 Vall6Ala (OT) No variant Superoxide Manganese (MnSOD) impact dismutase (mitochondrial) MnSOD SOD3 760 OG cc Superoxide Copper dismutase and Zinc (extracellular) CuZnSOD GPX1 GPX1 Prol98Leu CT Glutathione Selenium (C>T) peroxidase (GPx)
PCR/RFLP-based cost-effective identification of SOD2 signal (leader) sequence polymorphism (Ala-9Val) using NgoM IV: a detailed methodological approach.
7), peroxidase1 glutation (6,1), glutation peroxidasa 4 (3,6), SOD2 (3.
Three superoxide dismutases enzymes have been identified and characterized in mammals: cooper/zinc superoxide dismutase (Cu/ZnSOD encoded by SOD1 gene) manganese superoxide dismutase (MnSOD encoded by SOD2 gene) and the extracellular superoxide dismutase (ECSOD encoded by SOD3 gene) (Fridovich 1995; Miao and Clair 2009).