SOD1


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Related to SOD1: SOD2, SOD3, G93A

SOD1

A gene on chromosome 21q22.11 that encodes a soluble, copper- and zinc-binding cytoplasmic protein, which is responsible for destroying free superoxide radicals in the body, converting natural—but harmful—superoxide radicals to molecular oxygen and hydrogen peroxide.

Molecular pathology
SOD1 mutations have been linked to familial amyotrophic lateral sclerosis.
References in periodicals archive ?
Phase II/III randomized, placebo-controlled trial of arimoclomol in SOD1 positive familial amyotrophic lateral sclerosis.
Researchers cautioned that while a modified form of the SOD1 protein may play a part in sporadic cases of ALS, they still don't know what is causing the modification, how many cases may be as a result of the modification or whether it is the primary cause of the disease.
For instance, even though SOD1 protein is made everywhere in the body, and mutations that lead to overproduction cause aggregation of the protein in many tissues, only spinal cord neurons degenerate to give rise to ALS.
The best way to do that is to deliver the drug directly into the cerebrospinal fluid (CSF), which would reduce the amount of SOD1 suppression in cells outside the brain and reduce immune system exposure to V9-elements that would add weight to an argument for studying the drug in humans.
The 7 nuclear consensus MLST loci (CAP59, GPD1, IGS1, LAC1, PLB1, SOD1, and URA5) were amplified by using the preferred primer combinations (9).
SOD1 was identified in 1993, breaking open the world of ALS research.
Artavanis-Tsakonas's Consortium research focus will employ high throughput screens in Drosophila (often called "fruit flies") to identify genes that effect ALS dependent phenotypes resulting from expression of disease causing forms of SOD1, TDP-43 and FUS, and to identify protein complexes associated with ALS-related proteins in humans and Drosophila.
Wim Robberecht, MD, PhD, lead investigator of the latest study and a researcher at the University of Leuven in Belgium and the Vesalius Research Center, screened for genes in zebrafish that blunt the adverse effect of the ALS mutant gene SOD1.
47,48) Depletion of glutathione increases free radical damage that is known to occur in neurodegenerative diseases and has been linked to ALS in a transgenic SOD1 mouse model, says Lobner.
The MLST loci CAP10, CAP59, GPD1, IGS, LAC1, MPD1, PLB1, SOD1, TEF1 a, and URA5 of the environmental C.
Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons.
Similarly, it upregulated the expression of GPx, SOD1, and CAT mRNA in the liver.