SOD1


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia, Wikipedia.
Related to SOD1: SOD2, SOD3, G93A

SOD1

A gene on chromosome 21q22.11 that encodes a soluble, copper- and zinc-binding cytoplasmic protein, which is responsible for destroying free superoxide radicals in the body, converting natural—but harmful—superoxide radicals to molecular oxygen and hydrogen peroxide.

Molecular pathology
SOD1 mutations have been linked to familial amyotrophic lateral sclerosis.
References in periodicals archive ?
This study was also designed to find out the concentration of different metals and minerals in various genotypes of SOD1 gene polymorphism in RA patients as compared to control.
2006) with transmissible spongiform encephalopathy (TSE) have identified SOD1 gene as a candidate for prion diseases.
Phase II/III randomized, placebo-controlled trial of arimoclomol in SOD1 positive familial amyotrophic lateral sclerosis.
Daryl Bosco, assistant professor of neurology and lead author of the study, said in the release: "This common ALS pathology between sporadic and familial ALS means that current gene silencing and immunotherapeutic treatments being developed in academic and commercial labs that target the mutant SOD1 gene may be extended to target non-mutant SOD1 protein found in sporadic ALS cases.
For instance, even though SOD1 protein is made everywhere in the body, and mutations that lead to overproduction cause aggregation of the protein in many tissues, only spinal cord neurons degenerate to give rise to ALS.
When chimeric mice that included both normal and SOD mutant neurons in the same brain were used, those SOD1 neurons that were surrounded by many normal non-neuronal cells escaped the pathology and did not degenerate, while other SOD1 neurons that were surrounded by mutant neurons or nonneuronal neurons invariably degenerated.
The caspase-1- and caspase-3-like activities, as well as the level of interleukin-1beta, are significantly reduced in the spinal cord of symptomatic caspase-11-/-;SOD1 G93A mice compared with that of caspase-11+/-; SOD1 G93A mice.
Amazona farinosa: The following loci were fixed for the same allele in all taxa: ACP, ADA, AK, EAP, ES-MA, ES-NP1, ES-NP2, ES-NP3, FUM, GDA, GLUD, GOT1, GOT2, [Alpha]GPD, GPI, GSR, MDH1, MDH2, ME1, ME2, MPI, NADPH, PEP-LA, PEP-LGG, PGD, PGM1, PGM2, SOD1, SOD2, SORDH.
In addition, ProMIS Neurosciences owns a portfolio of therapeutic and diagnostic patents relating to misfolded SOD1 in ALS, and currently has a preclinical monoclonal antibody therapeutic against this target.
These genes encoded cytokines (CSF3, CSF2, CCL3, TNF, CCR1, IL13, KIT, CCL5, CCL4, IL10, CXCL10, IL12RB2, IFNG, IL1B, IL1A, IL8, MET, CD40, HGF, LEP, CXCL16, CX3CR1, CCR2, PDGFRA, IL12B, IL2), lipid metabolism related genes (CD36, GPX4, LPIN1, LPL, LPB), transcription regulators (BCL3, FOS and NFKBIA), receptors (TNF, IL8, RELA, TLR1, TIRAP, TLR2, NFKBIA, NFKB1, TLR4, CD40, CCL5, CXCL10, FOS, JUN, MAP3K8, IL1B, LBP, IL12B, CD14, SPP1), and others such as SELP, SELL, and SOD1, all play a role in some aspect of the immune response including cytokine activity (IL10, TNF, IL8, and IL1B), cell adhesion (SELL and SELP), immune activation (CD14 and TLR2), acute phase reaction (TNF, IL1B, and SAA3), apoptosis (BCL2, BAX).
Resveratrol can decrease expression of NOX1, NOX2, and NOX4, in addition to increasing SOD1 and glutathione peroxidase 1 expression (Spanier et al.
Elevated expression of MIF was shown to suppress accumulation of misfolded SOD1 in neuronal cells and extends survival of mutant SOD1-expressing motor neurons.