SOCS3


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SOCS3

A gene on chromosome 17q25.3 that encodes a protein which interacts with multiple activated proteins of the tyrosine kinase signalling pathway, including IGF1 receptor, insulin receptor and JAK2.

Molecular pathology
SOCS3 is thought to be a susceptibility gene for atopic dermatitis.
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Hypermethylation of the SOCS3 promoter was identified in 5 out of 19 (26.
Conclusion: The results revealed that promoter methylation of the SOCS3 gene suggests a possible role for SOCS3 methylation in the pathogenesis of MPNs and secondary erythrocytosis/thrombocythemia.
Key words: Myeloproliferative neoplasm, SOCS1, SOCS3, Secondary erythrocytosis/thrombocythemia
SOCS1 ve SOCS3 genleri JAK/STAT sinyal yolaginin negatif duzenleyicileridir.
Gerec ve Yontemler: SOCS1, SOCS3 genlerinin promotor metilasyonu, metilasyon spesififk PCR ile incelendi.
19 PV olgusunun 5'inde (%26,3), 21 ET olgusunun 2'sinde (%9,5), 5 PMF olgusunun (%20), 42 sekonder eritrositoz/trombositemi olgusunun 9'unda (%21,4) SOCS3 promotor metilasyonu saptandi.
Sontic: SOCS3 geni promotor metilasyonu MPN ve sekonder eritrositoz/trombositemi patogenezinde etkili olarak gorunmektedir.
Expression of SOCS1 and SOCS3 genes leads to reduced JAK and STAT phosphorylation via binding of the JH 1 domain and cytokine receptor of JAK, respectively (6), (7), (8).
SOCS2 and SOCS3 contribute to GH resistance in malnourished liver IGF-I deficient mice.
1) = CNRIP1 > ADHFE1 > FBN1(2) > FBN1(1) > SDC2 > UCHL1 > SEPT9 = VIM > THBD > SOCS3.
3) -- HLTF Helicase like transcription factor LAMA1 Laminin subunit alpha 1 NEUROG1 NEUROG1 Neurogenin 1 NGFR NGFR Nerve growth factor receptor RARB RARB Retinoic acid receptor beta RXRG RXRG Retinoid X receptor gamma RYR2 RYR2 Ryanodine receptor 2 SDC2 SDC2 Syndecan 2 SEPT9 SEPT9 Septin 9 SFRP2 SFRP2 Secreted frizzled-related SOCS3 SOCS3 Suppressor of cytokine signaling 3 SOX17 SOX17 SRY-box 17 THBD THBD Thrombomodulin Transmembrane protein with TMEFF2 TMEFF2 EGF-like and two follista- tin-like domains 2 UCHL1 UCHL1 Ubiquitin C-torminal hydro-lase L1 VIM VIM Vimentin Gene (a) Chromosomal (region) location (a) ADHFE1 8q12.
Emerging data on activation and function of STAT3 and SOCS3 in the lung during acute inflammation suggest that these molecules may regulate pulmonary inflammation (Gao and Ward 2007), and they have specifically been implicated in allergic airway inflammation (Paul et al.