FRS2

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FRS2

A gene on chromosome 12q15 that encodes an adapter protein which links activated FGR and NGF receptors to downstream signalling pathways. FRS2 plays a key role in activating MAP kinases and in phosphorylating  PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. FRS2 modulates signalling via SHC1 by competing with it for a common binding site on NTRK1. It is usually part of heteromultimeric protein complexes, and it is highly expressed in the heart, brain, spleen, lungs, liver, skeletal muscle, kidneys and testes.
References in periodicals archive ?
With a third party SNT, there is no Medicaid payback requirement.
Dibble said, "The opportunity to work with the SNT team is exciting and a welcome challenge.
In online trading, mobuy is the better alternative to EC card and credit card payments, as consumers do not have to divulge any confidential data", says sales director Herman Kasch from SNT Multiconnect.
Each of 2 unweaned pups matched their mother's serostatus, with 1 pup positive by SNT (pup 80, mother >640).
By implementing SNT functions in OTS, the separate Web-based Serial Number Tracking System (SNTS) will be retired.
SNT also provides custom solutions and engineering support services for specific customer requirements.
With future reductions in supportive services, authorizing the trustee of a SNT to invest in residential real estate for the beneficiary's housing needs can significantly help assure long-term protection for the child as beneficiary.
Ernst & Young LLP, advisers to Gartmore SNT PLC 020 7951 53 24
The SNT project and presentation were infectious to the audience, causing a great deal of interest in what the Navy has done with Serial Number Tracking.
the SNT is created under the parent's will or revocable living trust).