SNCA


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Related to SNCA: SNAC, SBCA

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
If further study finds that this risk is conferred via a mechanism of gene overexpression, interventions targeting SNCA expression may reduce the risk of developing PD in susceptible populations.
Speeding Therapeutics Against Two Promising Targets PPMI will enroll individuals with a mutation of the LRRK2 or SNCA gene.
Alpha-synuclein therapies can be tested in all Parkinson's patients, but individuals with the SNCA mutation present another population of interest to study the effects of candidate drugs.
Currently known genetic subtypes, such as SNCA, LRRK2, and PARK2, can classify and diagnose only five to ten percent of patients with Parkinson's disease; however, the genetic discoveries from this collaboration are anticipated to dramatically boost the diagnostic yield of genetic testing in Parkinson's patients.
SNCA is in need of the supplier who can provide services and products for interior signage.
Initial discussions with SCP(R) include plans for the development and delivery of several SCP certifications including SNCS, SNCP and SNCA.
SNCA promises no volume guarantee but together so suborder Courts Administration and other authorities in the Courts of Sweden information database services for approximately 8 million SEK per year.
SNCA is in need of supplier who can provide catering services to the Courts Administration training facility at Torsgatan 11, Stockholm.