SNCA


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Related to SNCA: SNAC, SBCA

SNCA

A gene on chromosome 4q21 that encodes alpha synuclein, which may be involved in regulating dopamine release and transport. SNCA induces fibrillisation of microtubule-associated protein tau, reduces neuronal responsiveness to apoptotic stimuli, and downregulates caspase-3.
References in periodicals archive ?
The current study was designed to find out possible association of SNCA polymorphisms in PD patients and spectrum of these polymorphisms.
Genes associated with an autosomal dominant pattern of inheritance include SNCA and LRRK2, while autosomal recessively inherited gene abnormalities include parkin, DJ-1, PINK1 and ATP13A2.
Several case-control studies and genome-wide association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the SNCA gene and Parkinson's disease (PD) and have provided inconsistent results.
An examination of trans-effects revealed 23 DNA sequence variations that reached statistical significance involving variants from the SNCA, MAPT and RIT2 genes.
They used data from the Genetic Epidemiology of Parkinson's Disease Consortium to investigate SNCA gene mutations in what they described as "the largest case-control study of PD to date.
En principio, recuerda que el Fonca fue fundado en 1989, cuando presidia el Conaculta el diplomatico e intelectual Victor Flores Olea, quien "siempre se nego a crear el SNCA; penso que el Fonca era una forma de tener fondos concursables y el SNCA era mas bien senalar a creadores insignes, estimular solamente a las personas mas importantes del medio, y decia que esa era una forma de tener intelectuales y artistas poco criticos al sistema".
A genetic aetiology has been found in ~10-15% of PD cases and a number of genes (and corresponding proteins) have been implicated, including parkin, PINK1 (PTEN-induced putative kinase 1), DJ-1 (DJ-1), SNCA ([alpha]-synuclein), LRRK2 (leucine-rich repeat kinase 2), VPS35 (vacuolar protein sorting 35) and EIF4G1 (eukaryotic translation initiation factor 4 [gamma]1).
Currently known genetic subtypes, including SNCA, LRRK2 and PARK2, can classify and diagnose 5%-10% of Parkinson's patients.
SNCA ([alpha]-synuclein), LRRK2, PINK1 (PTEN-induced putative kinase 1), PARK2 (parkin)] have been used for PD research (Bezard et al.
A lo largo de los anos, los apoyos se han subdividido de la siguiente forma: 1,612 se han concedido para estudios o estancias en el extranjero; 82 para traduccion literaria (que se cuenta como parte del rubro de "coinversiones" a partir 2007); 1,906 se han entregado en la categoria de "jovenes creadores"; 1,282 a creadores escenicos o ejecutantes; 134 a escritores en lenguas indigenas (que, desde 2007, pasaron a integrarse como categoria permanente en "jovenes creadores" y en el SNCA); y, finalmente, 1,874 han sido destinados a proyectos de "coinversion y apoyo" y 6,156 (la parte del leon) han ido a parar a creadores del ya mencionado SNCA.
19) SNCA is 'a protein thought to be involved in the regulation of dopamine release and transport.
The SNCA gene is a well-known risk factor for Parkinson's disease, and higher levels of the a-synuclein protein made from this gene are associated with greater disease severity in familial cases of Parkinson's.