MYH11

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MYH11

A gene on chromosome 16p13.11 that encodes a heavy chain of myosin and is thus involved in cytokinesis, cell shape and specialised functions—e.g., secretion and capping.
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Bcl2, B-cell chronic lymphocytic leukemia (CLL)/lymphoma; CD, cluster of differentiation; CK, cytokeratin; MEC, myoepithelial cells; SMMHC, smooth muscle myosin heavy chain.
In our practice, we use a panel of 3 single stains: SMMHC, calponin, and p63.
They observed a reduced expression of CK5/6 in 32% of cases, SMMHC in 20%, CD10 in 15%, p63 in 10%, and calponin in 6%, compared to that of normal MECs.
In adenoid cystic carcinoma, the pattern is interesting: while p63 staining is positive in the basal-like cells, staining with calponin and SMMHC is negative.
The sensitivities of CK5/6, CK14, and CK17 for MECs are, in our experience, comparable to those of SMA, MSA, p63, and SMMHC, whereas 34[beta]E12 (which recognizes CK1, CK5, CK10, and CK14) exhibits considerably lower sensitivity.
Markers SMA (Figure 4), MSA, calponin, p63 (Figures 3, C and 5), maspin, p75, and SMMHC (Figure 2, B) are probably largely comparable in their sensitivities for MECs for scenarios in which the question is invasive carcinoma versus an entirely benign process, with the important caveat that sclerosing lesions of the breast may show patchy or no staining in a significant subset.